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mTOR and 4E-BP: Duo playing nice roles in Cells.

Date: 28 May 2010
Member: Jitendra Sinha


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mTOR also known as FRAP1, is a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, and transcription.
Visit: http://www.sciencemag.org/cgi/reprint/328/5982/1172.pdf

Dowling et al 2010 found that 4E-BPs inhibit translation of messenger RNAs that encode proliferation-promoting proteins and proteins involved in cell cycle progression and hence the cell proliferation; with no effect on cell size. They further say that there is no correlation between control of cell size and cell cycle progression in mammalian cells, but in the lower eukaryotes, 4E-BPs influence both cell growth and proliferation.

Last Updated on 28 May 2010

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