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H-FABP: A Global Biomarker of Myocardial Ischemia & Acute Coronary Syndrome

Date: 2012-02-02 03:18:21 Member: Randox Laboratories Views: 226 Discipline: Clinical / Health / Medicine Link: http://www.youtube.com/watch?v=R0ccJKWEOa4&feature=related

  This is the world's first CE marked automated chemistry assay for Heart-type Fatty Acid Binding Protein (H-FABP), a highly sensitive & specific marker of myocardial ischemia.

H-FABP is a low molecular-weight (15kD) cytoplasmic protein that is involved in the intracellular uptake and buffering of free fatty acids in the myocardium . The combination of its low molecular weight and cytoplasmic location enables H-FABP to be a highly sensitive early rise marker of acute coronary syndrome (ACS), detectable as early as 30 minutes following the onset of an ischemic episode . H-FABP concentrations peak at approx. 6-8 hours and return to normal within approx. 24-30 hours . Although H-FABP has similar release kinetics to Myoglobin, it is approx 15-20 times more cardiac specific, hence making it a more effective marker of myocardial injury .

Using a combination of H-FABP and Troponin has been shown to significantly improve the diagnostic sensitivity for MI/ACS during the early hours after symptom onset, compared to using Troponin alone. Prognostically, a number of large trials have illustrated the value of H-FABP in stratifying long-term ACS risk in both Troponin positive and Troponin negative patients. H-FABP has also be shown to be incrementally additive to Troponin, diagnostically and prognostically, even when a highly sensitive Troponin assay is used .

In addition to ACS, H-FABP has been found to be clinically useful in a range of other applications, such as pulmonary embolism (PE) , coronary artery bypass surgery (CABG) and cerebrovascular disease.

http://www.randox.com/H-FABP_automated_assay.php

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