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Therapeutics Antibody Characterization
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Mon April 1st, 2013
Scientists Found Novel Monoclonal Antibody for CLL Chronic lymphocytic leukemia (CLL) is one ki
Scientists Found Novel Monoclonal Antibody for CLL Chronic lymphocytic leukemia (CLL) is one kind of blood cancer. It is the second most common type of leukemia in adults. It is also the most common type of blood cancer in America. According to authentic statistics, it is estimated that 16,060 men and women will be diagnosed with and 4,580 men and women will die of CLL in 2012. Thus CLL is an urgent issue. Several days ago, researchers claimed that they have identified a humanized monoclonal antibody that can target and directly kills CLL cells. The monoclonal antibody-RG7356 that specifically targeted CD44, which is highly expressed in CLL and was directly toxic to cancer cells, but had little effect on normal B cells. This discovery offers a promising path for people to develop countermeasures. In the process, they also found the monoclonal antibody induced CLL cells that expressed the protein ZAP-70 to undergo apoptosis or programmed cell death. The protein is express
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