JUL 27, 2022 9:00 AM PDT

Accelerating strain development process for CDMO and CRO companies

Sponsored by: Inscripta
Speaker

Abstract
Date:  July 27, 2022
Time: 9:00am (PDT),  12:00pm (EDT), 6:00pm (CEST)
 
Manufacturing of proteins, mRNA or small molecules requires comprehensive strain engineering approaches to increase yield, productivity, and robustness of the strain. While some of these goals can be accomplished with standard genetic engineering methods, others require a whole-genome, exploratory approach that can take many months. With the Onyx® Digital Genome Engineering platform, you can go after each of these objectives simultaneously by generating diverse strain libraries in a simple, automated workflow. Insertions, deletions, and substitutions across multiple targets, such as promoters, coding regions or global regulators, can be rapidly introduced to improve both specific functions and the overall manufacturability of the strain. In this webinar we will demonstrate how this approach helped improve production of heterologous proteins in E. coli and S. cerevisiae.   
 
Learning Objectives
  • Utilize targeted & genome wide approach to significantly shorten the strain development cycle
  • Show that edits essential to protein production span multiple pathways: transcription, translation, secretion and protein degradation
  • Employ shallow sampling to find hits in the library with greater than 2-fold protein expression improvements
 
 
Webinars will be available for unlimited on-demand viewing after live event.
 

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