JAN 21, 2021 8:00 AM PST

Critical reagent characterization for regulated bioassays accelerated by Uncle

Sponsored by: Unchained Labs
  • Partner and CSO, B2S Life Sciences
      Dr. Bowsher’s career in the pharmaceutical/biotechnology and CRO industries has spanned 4½ decades, including 3 decades at the Lilly Research Labs and nearly 2 decades as a consultant and an advisor in the CRO industry. He is a recognized thought-leader in the areas of bioanalytical methods development for regulatory-compliant bioanalysis, ADME and immunogenicity assessments of biotherapeutics. He received his M.S. and Ph.D. degrees in Biochemistry & Molecular Biology at the Indiana University School of Medicine (Indianapolis, IN).
      Currently, he is Partner and CSO at B2S Life Sciences™ (www.B2SLifeSciences.com), a biotechnology drug enablement company located in Franklin, IN that specializes in the generation and life-cycle management of custom biological reagents, ligand binding assay development and ADME, and data analytics to support biotherapeutic drug development.In 2004, Dr. Bowsher was elected as an AAPS Fellow and was given an AAPS Presidential citation in 2008 for his efforts to establish educational training programs for supporting Biotech R&D. In 2011, Dr. Bowsher received the AAPS BIOTEC Section distinguished service award.
    • Scientist - Custom Reagents, B2S Life Sciences
        Adam Kinne is a Scientist in the Custom Reagents group of B2S Life Sciences. He is currently engaged in the production and characterization of reagent antibodies, bioconjugates, and other proteins. He has previously worked as a synthetic chemist in proteomics, a researcher in inorganic chemistry, and an analytical chemist for an agricultural product manufacturer.
      • Marketing Manager, Unchained Labs
          Kevin Lance is the Marketing Manager covering Uncle at Unchained Labs. He has published works and secured patents in the fields of sustained antibody delivery and nanotechnology, and has worked as a consultant to advance the development of biologics for several major biopharmaceutical companies. He earned his Ph.D. in Bioengineering from the joint UC Berkeley – UCSF Bioengineering Graduate Program.

        Date:  January 21, 2021
        Time: 8:00am (PST),  11:00am (EST),  5:00pm (CET)
        Today, critical reagent characterization is a key component in the overall workflow to establish robust ligand binding assays (e.g., immunoassays) for supporting the discovery and development of new biotherapeutic drugs. At B2S Life Sciences we have incorporated the Unchained Labs Uncle instrument into our comprehensive workflow to augment our detailed characterization of critical reagents. Our webinar will present two case studies where the Uncle technology provided crucial data about structural characteristics, which heretofore were not attainable by commonly used characterization methodologies, that enabled timely decision-making and decreased resource utilization. One major benefit of the Uncle is its ability to generate this key information using < 10 μL of test sample.
        The first case study compares the characterization of two enzymes, where a difference in primary sequence resulted in differential aggregation behavior. Uncle DLS and Tm/Tagg data enabled selection of the correct isozyme for use in a critical assay. In the second case study we used the Uncle in early-phase drug development as the investigative tool to aid candidate selection for a series of bioconjugates. Case studies will highlight dynamic light scattering (DLS) and protein melting/aggregation (Tm/Tagg) analyses in the context of broader workflows for protein characterization.
        Learning Objectives
        • How Uncle can supplement or replace more traditional characterization workflows
        • How Tm/Tagg measurements can support candidate selection or critical reagent selection
        • How the Uncle can accelerate drug development to enable efficient decision-making that results in decreased resource utilization and cost savings
        Webinars will be available for unlimited on-demand viewing after live event.

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