JUN 15, 2012 8:00 AM PDT

Establishment of the D-dimer Assay in the Clinical Laboratory

Sponsored by: Diagnostica Stago, Inc.
  • Professor of Pathology Chief, Clinical Pathology, VA Medical Center, Department of Pathology, University of Oklahoma Health Sciences Center
      Richard Marler, Ph.D Dr Marlar is Professor of Pathology at the University of Oklahoma. He serves as the Chief of Clinical Pathology at the Oklahoma City VA Medical Center. He has directed Coagulation Laboratories for 30 years including currently the Coagulation Labs at the University of Oklahoma Medical Center and the Routine and Special Coagulation Laboratories at the Oklahoma City VA. In addition he oversees the Molecular Diagnostics Laboratory at the Oklahoma City VA. He received his PhD from Wayne State University in Biochemistry and Physiology and did a Hemostasis Fellowship at the Scripps Clinic and Research Foundation. He serves on numerous national and international clinical coagulation committees including: CLSI Committee on Coagulation, Director of External Quality Assurance for the North American Special Coagulation Laboratory Association (NASCOLA), Co-Chairman of the ISTH Committee on Plasma Inhibitors, the International External Quality Assessment Program for Thrombosis and Hemostasis, and the CAP Coagulation Resource Committee. He is currently the Editor of the international journal Blood Coagulation and Fibrinolysis . His research focuses on the genetics of venous thrombosis and thrombophilia with special interest in protein C deficiencies. He also conducts translational research for the clinical laboratory. He is the author of over 135 articles, book chapters and monographs.


    The purpose of this educational activity is to review the clinical utility of the D-dimer assay and present details of a successful method to establish and validate the D-dimer assay in the laboratory for the exclusion of Venous Thromboembolism.

    • Understand the process of D-dimer formation.
    • Recognize the advantages and pitfalls of the D-dimer assay.
    • Discuss and implement the method to validate and establish an accurate cut-off value for the D-dimer assay.
    • Discuss cost saving scenarios by using the D-dimer assay.
    • Discuss possible future uses of the D-dimer assay in clinical medicine.

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