Lupus anticoagulants occur in patients, increase their risk of thrombosis and may or may not be associated with other disease states such as systemic lupus erythematosus (SLE).  Detection of lupus anticoagulants and confirmed diagnosis of associated antiphospholipid syndrome (aPS) requires use of multiple assays utilizing clotting as well as solid phase methodology, along with confirmation of the clinical etiology.  The purpose of this program is to update healthcare professionals regarding advancements in aPS and LA testing. Current LA diagnostic guidelines, additional aPS testing, clinical evidence regarding LA testing methodologies, and case studies will be presented.

• Describe antiphospholipid syndrome (aPS) and the role of lupus anticoagulant (LA) in thrombosis.
• Present current guidelines for LA screening and confirmation.
• Discuss recommended LA testing methodologies.
• Correlate LA and aPS to specific clinical cases.