JUN 25, 2020 8:00 AM PDT

Mass Spectrometry Past and Present - Emerging Technologies and Strategies for Quality Management in Today's Clinical Laboratory

Sponsored by: Waters Corporation
C.E. Credits: P.A.C.E. CE Florida CE
  • Clinical Section Chief of Biochemistry in South Sector at Alberta Precision Laboratories (APL); Clinical Professor of Pathology and Laboratory Medicine (DPLM) at the University of Calgary
      He received his graduate degrees (MS and PhD) from the University of Minnesota in Minneapolis and continued his postgraduate training in Clinical Chemistry at the University of Washington in Seattle. Certified in Clinical Chemistry by the American Board of Clinical Chemistry and the National Registry in Clinical Chemistry, Dr. Sadrzadeh has directed clinical chemistry and toxicology laboratories at different institutions such as Harvard Medical School, the University of Arizona, and the University of Washington in Seattle, Cedars Sinai Medical Center and APL for over 25 years. Also, as a director of graduate and postdoctoral fellowship programs, he has devoted most of his academic life to medical education and has trained over 65 clinical chemistry fellows, residents, graduate and undergraduate students.

      Dr. Sadrzadeh is a widely recognized clinical chemist and scientist who has authored over 220 peer reviewed articles, book chapters, monographs, abstracts, and co-edited a book. His research interests have been mostly focused on the role of iron, hemoglobin and haptoglobin in initiating or modulating oxidative stress and tissue injury in neurodegenerative and metabolic disorders. He has been funded by NIH, JDRF and several other funding agencies in the US and Canada. He has been an invited speaker at regional, national and international venues.

      Dr. Sadrzadeh also directs clinical projects aimed at developing new markers and methods using LC-MS/MS technology. He has successfully implemented LC-MS/MS systems in different clinical laboratories in the past 20 years.
    • Clinical Biochemist, Alberta Precision Laboratories, Clinical Assistant Professor, University of Calgary
        Dennis Orton is a Clinical Biochemist overseeing the Mass Spectrometry testing laboratory in Calgary for Alberta Precision Labs with a cross appointment as a Clinical Assistant Professor at the University of Calgary. He has a background in proteomics research, and completed his PhD at Dalhousie University in Halifax, NS, Canada at the interface between Pathology and Analytical Chemistry. His current research interests involve development of LC-MS assays to elucidate a greater understanding of individuals' responses to drug therapy and pharmacokinetics.
      • Clinical Biochemist, Alberta Precision Laboratories, Clinical Assistant Professor, University of Calgary
          Jessica Boyd is a Clinical Biochemist at Alberta Precision Laboratories (Calgary) and a Clinical Associate Professor at the University of Calgary. She is the co-director of the Analytical Toxicology Laboratory which includes mass spectrometry testing for urine drugs of abuse, therapeutic drug monitoring and endocrine markers. Dr. Boyd completed her Ph.D. in Analytical and Environmental Toxicology at the University of Alberta in 2012 and Clinical Biochemistry Fellowship training at Calgary Laboratory Services/University of Calgary in 2015.

        DATE:  June 25, 2020
        TIME:  8:00am PDT, 11:00am EDT, 4:00pm BST, 5:00pm CEST
        Mass Spectrometry (MS) has been an invaluable tool for physicists and basic chemists for over 100 years. It was not until around 30 to 40 years ago that technological advancements in ionization and sample preparation allowed for clinical applications to flourish. In the clinical lab, MS technology have mostly been limited to large reference laboratories due to instrument cost and complexity, but this is rapidly changing as advancements in user-friendly software, commercially available kit methods and simplified workflows become available. Services such as high resolution MS for toxicology, matrix-assisted laser desorption ionization (MALDI) MS for bacterial identification, and triple quadrupole MS for therapeutic drug monitoring and endocrinology applications have become more common in recent years, and with imminent expansion to the fields of anatomic pathology, hematology, and point of care, it is more important than ever for laboratory staff and leadership to have a fundamental understanding of MS, relevant quality metrics, and troubleshooting strategies. This presentation will provide a historical perspective on MS in the clinical lab, discuss some of the technologies currently available and provide insight on advances in automation, sample preparation and LIS interfacing. Additionally, we will review some real-world applications of MS with focus on accreditation and quality metric monitoring (e.g. system suitability samples, QC and calibrator preparation, lot-to-lot validations, and hydrolysis efficiency). We will cover some common troubleshooting scenarios such as a sudden losses of instrument sensitivity, chromatography performance degradation, ion suppression, and inconsistent internal standard recovery. Specific case studies will be covered to give examples of where MS applications provide superior performance to other assays, including detection and quantification of M-proteins in multiple myeloma, hormones, and therapeutic drugs.
        Learning Objectives:
        • Discuss the history of MS technologies
        • Compare the strengths and weaknesses of different types of mass spectrometry
        • Understand the necessary quality metrics required to ensure assay quality and meet accreditation standards
        • Discuss basic troubleshooting tricks to deal with problems or improve assay robustness
        Webinars will be available for unlimited on-demand viewing after live event.
        LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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