Traditional genomics approaches look at bulk signatures from often heterogeneous samples or tissues. These approaches do not have the requisite resolution to fully uncover the true complexity of biology. Single cell and spatial transcriptomics approaches provide the ability to build a more comprehensive multidimensional understanding of complex biological systems. In order to fully utilize such technologies, there are several key experimental design and sample preparation considerations that when followed will help lead to success. Both single cell and spatial transcriptomics provide high resolution views, and we will discuss how combining both of these technologies work synergistically to uncover an even greater understanding.
1. Understand the key requirements for sample preparation in a single cell and/or spatial transcriptomics experiment
2. Learn the synergies between a combined single cell and spatial transcriptomics approach