APR 29, 2020 9:00 AM PDT

The THUNDER Imager EM Cryo CLEM - How to identify and retrieve your cellular targets for Cryo Electron Microscopy

Sponsored by: Leica Microsystems
C.E. Credits: P.A.C.E. CE Florida CE
  • Application Manager - Correlative Microscopy, Leica Microsystems CMS GmbH
      Jan works as a microscope professional in different roles since 20 years. He joined Leica in 2011 as a product specialist for confocal microscopy. In 2017 he became member of the newly formed Workflow Team being responsible for correlative workflows, in particular involving cryo sample preparation and cryo microscope systems.
      Jan studied biology and did his PhD in the field of olfaction, characterizing olfactory neurons in their response to odorants.

    DATE:  April 29, 2020
    TIME:   9:00am PT, 12:00pm ET
    Recent revolutionary developments in the field of cryo electron microscopy (EM) revealed cellular mechanisms in subnanometer resolution. Unfortunately, it is very challenging to identify and localize structures of interest in the cryo TEM alone. To facilitate this, cryo workflows have been established integrating cryo light microscopes for sample assessment and target identification. The THUNDER Imager EM Cryo CLEM is a cryo light microscope used to identify and mark fluorescent structures in vitrified cellular samples for easy retrieval in the subsequent cryo EM preparation steps. The THUNDER technology employs the innovative Leica method of Computational Clearing to eliminate out-of-focus blur, that can occur with widefield observation. The result is crisp, haze-free images for more precise identification of cellular target structures.
    This seminar presents the system and it´s integration into state-of-the-art cryo EM workflows.
    Learning Objectives:
    • Why are cryo EM workflows so revolutionary?
    • Why is the integration of a cryo light microscope essential?
    • What is the THUNDER technology?
    Webinars will be available for unlimited on-demand viewing after live event.
    LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.


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