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My research interests are in enteric virus infections - particularly norovirus and enterovirus - and the virological features of these viruses that drive their highly dynamic epidemiology, allowing them to emerge and persist in human populations.
Enteric virus infections associated with gastroenteritis are common among humans. Whilst illness is usually mild and self-limiting, viral gastroenteritis causes substantial morbidity in the population: in particular, that associated with norovirus which has an estimated incidence in the UK community of three million cases each year. The plasticity of the norovirus genome and error-prone nature of its replication allows for the generation of genetically diverse populations of viruses that co-circulate, and selective pressure drives selection and the periodic emergence of novel strains.
My current research interests are focused in two main areas:
(1) evolution of the antigenic profile of a virus under selective pressure of host and population (herd) immunity; and
(2) the virus-host interactions made during the early stages of infection.
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