JUN 14, 2016 01:31 PM PDT

One Tiny RNA Could Break the Cycle of Arterial Thrombosis

WRITTEN BY: Kara Marker
Medication to dissolve blood clots and various surgical procedures can be done to reverse damage done to arteries with obstructive blood clots, a condition called arterial thrombosis. However, scientists have discovered a more natural way to resolve this condition to prevent increased risk of heart attack and stroke, and without resorting to invasive surgery.
Image Credit: UNC School of Medicine
MicroRNAs (miRNAs) are tiny molecules that play a big role in gene expression regulation. At only 22 nucleotides long, these single-stranded molecules are some of the shortest of known genetic material, and scientists in a new study published in The FASEB Journal believe their gene expression regulation capabilities could extend to proteins and genes involved in the development of arterial thrombosis.
 
In their study, scientists from Brigham and Women’s Hospital drew upon previous knowledge that a specific type of microRNA called miR-181b regularly balances the impact of both acute and vascular inflammation. Arterial thrombosis often results from arterial damage due to atherosclerosis, a condition that consists of plaque deposits in the blood vessels that can be exacerbated by inflammation. When these atherosclerotic plaques rupture, obstructive blood clots can form.
 
They saw that miR-181b targets a protein called Card10, which is involved in activating inflammation through apoptosis signaling and other highly specific interactions with other proteins. If inflammation isn’t under the right control, blood clots can form continuously, causing a “vicious cycle” of arterial thrombosis.
 
Building on this observation, researchers conducted preclinical studies of mouse models of thrombosis in the carotid artery. When they delivered a supply of miR-181b to these mice, they saw a 73 percent reduction in blood clot formation as well as a significant increase in the time the arteries took to become blocked. Similarly, when they went right to the suspected source of the blood clot formation, Card10, and directly blocked its activity, they saw the same trends in reduction.
 
Corresponding author Mark Feinberg explained the study’s significance:

“Delivery of miR-181b or Card10 inhibition may constitute a new therapeutic approach to reduce arterial thrombosis.”

 
This study has significant implications for conditions closely related to arterial thrombosis: heart attack, stroke, and peripheral artery disease.
 

 
Sources: Brigham and Women’s Hospital, Exiqon, National Health Service, Gene Cards Human Gene Database
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUL 15, 2019
Cardiology
JUL 15, 2019
Study Provides Dependable Method Of Calculating Exercise Intensity For Walkers
An ongoing study from the University of Massachusetts Amherst has found that walking cadence is a reliable measure of exercise intensity. This allows resea...
JUL 15, 2019
Cardiology
JUL 15, 2019
How Perception Shapes The Exercise Experience
It’s only the end of February, but chances are you’ve left your New Year’s resolution far behind you. If that resolution was to get in be...
JUL 15, 2019
Cardiology
JUL 15, 2019
How Diets Fail Us
If you’ve ever started a diet plan, you are well aware of how difficult that can be. Most people who successfully lose weight eventually gain it back...
JUL 15, 2019
Cardiology
JUL 15, 2019
Female Athletes Forced To Suppress Natural Hormone Levels To Compete
Tests exist today that could easily determine if a female were introducing synthetic testosterone into their system in hopes of enhancing performance. Rega...
JUL 15, 2019
Health & Medicine
JUL 15, 2019
Pregnancy Related Deaths Are Largely Preventable
A new report from the Centers for Disease Control (CDC) highlights just how poor maternal health is in the United States. Although data is limited, the dat...
JUL 15, 2019
Cardiology
JUL 15, 2019
Soda Taxes Reduce Consumption
We know that over-consuming sugary drinks is not good for us. Regardless many of us still struggle to fight off that urge. In 2010 Coca-Cola sold over 900...
Loading Comments...