AUG 01, 2021 9:07 AM PDT

Berry Compound Reverses Parkinson's in Mice

WRITTEN BY: Annie Lennon

A naturally-occurring compound called farnesol found in berries and other fruits prevents and reverses Parkinson's-associated brain damage in mice. The study was published in Science Translational Medicine by researchers in the US and South Korea. 

Parkinson's disease occurs due to a loss of neurons in the brain that produce dopamine. This loss of neurons is thought to happen due to a build-up of PARIS, a protein that slows down the production of a protein called PGC-1alpha that shields brain cells from damaging oxygen molecules. Without PGC-1alpha, dopamine neurons die, leading to symptoms of Parkinson's disease.

In experiments, the researchers fed mice a farnesol-supplemented diet or a normal mouse diet for a week. They then gave the mice pre-formed fibrils of the protein alpha-synuclein, which mimic the effects of Parkinson's disease in the brain. In the end, they found that mice fed farnesol-rich diets performed an average of 100% better on strength and coordination tests used to detect the advancement of Parkinson's disease. 

The researchers later studied the brain tissue of mice from the two groups. In doing so, they found that those fed on farnesol had twice as many healthy dopaminergic neurons as those on the conventional mouse diet. Mice receiving supplements also had around 55% more PGC-1alpha in their brains than those on regular diets. 

The researchers later confirmed in chemical experiments that farnesol works by binding to PARIS and changing its shape to not interfere with PGC-1alpha production. 

The amount of farnesol currently consumed by people is unknown- both in natural and synthetic form. Moreover, safe doses of farnesol for humans are yet to be determined by clinical trials. This means that further research is needed before farnesol supplementation could begin to be considered for humans to prevent or reverse Parkinson's disease. 

 

Sources: Science Translational MedicinePubChemNeuroscience News

About the Author
  • Annie Lennon is a writer whose work also appears in Medical News Today, Psych Central, Psychology Today, and other outlets. When she's not writing, she is COO of Xeurix, an HR startup that assesses jobfit from gamified workplace simulations.
You May Also Like
JUL 07, 2021
Cancer
Chemotherapy Disrupts Gut Bacteria in Cancer Patients
JUL 07, 2021
Chemotherapy Disrupts Gut Bacteria in Cancer Patients
Researchers from Australia have found that the conventional chemotherapy used to treat various cancers disrupts the comp ...
JUL 20, 2021
Technology
Artificial Intelligence Predicts Which Drug Candidates Will Be Successful In Clinical Trials
JUL 20, 2021
Artificial Intelligence Predicts Which Drug Candidates Will Be Successful In Clinical Trials
Researchers are leveraging artificial intelligence and machine learning to help improve the rate at which drugs move suc ...
AUG 05, 2021
Cannabis Sciences
Brain's Version of THC Reduces Seizures, Increases Side Effects
AUG 05, 2021
Brain's Version of THC Reduces Seizures, Increases Side Effects
An endocannabinoid similar to tetrahydrocannabinol (THC) that naturally occurs in the brain reduces seizure activity. Ho ...
AUG 12, 2021
Cancer
Promising Drug Target Identified for Deadly Ovarian Cancer
AUG 12, 2021
Promising Drug Target Identified for Deadly Ovarian Cancer
Scientists at the University of Alabama at Birmingham have identified a gene called DOT1L for its role in progressing th ...
AUG 13, 2021
Cell & Molecular Biology
Taking Aim at the Sugar Coat of the SARS-CoV-2 Spike Protein
AUG 13, 2021
Taking Aim at the Sugar Coat of the SARS-CoV-2 Spike Protein
We've learned a lot about the virus that causes COVID-19, SARS-CoV-2, in the past year and a half. Researchers know the ...
SEP 17, 2021
Cell & Molecular Biology
How Stem Cells May Aid in the Treatment of MRSA
SEP 17, 2021
How Stem Cells May Aid in the Treatment of MRSA
MRSA (methicillin-resistant Staphylococcus aureus) is a well known superbug, a pathogenic microbe that can cause serious ...
Loading Comments...