AUG 27, 2018 08:56 PM PDT

Anemic Drug Re-purposed To Treat Heart Failure in Diabetics

WRITTEN BY: Nouran Amin

According to a study funded by the British Heart Foundation (BHF) and Diabetes UK, drugs in development to treat anemia can now be repurposed to help prevent people with Type 2 diabetes from heart failure. The study was published in the Journal of American Cardiology and discusses how a protein by the name of HIF was found to help cardiomyocytes (heart cells) thrive after a heart attack.

In diabetics, fats aggregate within the heart muscle and cause the activity of the HIF protein to be inhibited. In other words, a diabetic will then be more likely to suffer a lasting heart muscle damage and develop heart failure after a heart attack. "After a heart attack, people with Type 2 diabetes are more likely to develop heart failure more quickly, but we have not fully understood the reasons why that is the case,” explains Dr. Lisa Heather, a BHF researcher from the University of Oxford and lead author of the study.

When scientists from the University of Oxford treated diabetic rats with a compound responsible for activating the HIF protein, they were motivated to help the heart heal after a heart attack. However, this is not definitive as plenty of research is needed to see if this process is possible to replicate in humans. the heart to recover from a heart attack. Further work is needed to see whether the same process can be replicated in people.

"What we have shown with this research is that the metabolism of people with Type 2 diabetes means they have higher levels of fatty acids in the heart. This prevents signals going to the heart protective protein telling it to 'kick-in' after a heart attack. But what is perhaps most exciting, is that existing drugs -- currently being trialed for people with blood disorders -- can reverse that effect and allow the protein to be activated after a heart attack. This opens the possibility that, in the near future, we could also use these drugs to help treat heart attacks in people with Type 2 diabetes."

Watch this video below to understand more on the relationship between diabetes and the heart!

Source: British Heart Foundation

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
OCT 06, 2018
Drug Discovery
OCT 06, 2018
New Class of Drugs for Breast Cancer Therapy
Scientists at Stevens Institute of Technology have designed a new class of molecules that may hold the potential to add to the arsenal of drugs actively be...
NOV 15, 2018
Drug Discovery
NOV 15, 2018
Treating Restless Leg Syndrome (RLS)
A common condition of the nervous system, Restless Leg Syndrome (RLS) is the overwhelming urge to move the legs. Usually unpleasant symptoms, many RLS pati...
NOV 21, 2018
Drug Discovery
NOV 21, 2018
Drug Could Seek New Approach For Autoimmunity
From a failed pain drug, a protein called ‘BH4’, was recently discovered to have surprising implications in the treatment of autoimmunity and c...
NOV 24, 2018
Drug Discovery
NOV 24, 2018
New Anti-Malarial Drug Target in Cancer
For decades, anti-malaria drugs--known as Chloroquines, have used to treat cancer. But the role in repurposing these drugs for slowing tumor growth have ne...
JAN 23, 2019
Drug Discovery
JAN 23, 2019
Frequent Aspirin Use Can Lead to Increased Bleeding
According to a systemic study published in the Journal of the American Medical Association (JAMA), taking aspirin regularly may prevent heart attacks and s...
FEB 08, 2019
Drug Discovery
FEB 08, 2019
Bodybuilding Supplement Harms Brain Cells
Researchers at University of Technology Sydney warn that the protein supplement, L-norvaline, could damage brain cells. The study was published in Toxicolo...
Loading Comments...