MAY 23, 2019 11:29 PM PDT

Long-Lasting Worms Inspires Anti-Aging Drugs

WRITTEN BY: Nouran Amin

Researchers have recently discovered that aging in nematodes may be partially controlled and can be therapeutically reversed through multiple FDA-approved drugs. Findings of the research were published in Scientific Reports.

One such nematode, C.elegans, and the most intensively studied animals on Earth had its genome the first sequenced among multicellular organisms. They hold lifespan of 15 to 25 days allowing them to become a convenient model organism for aging studies.

Learn more about C. elegans:

"Our main concern was that aging in an extremely long-living worm might be totally different from that of normal, wild-type nematodes. In that case, the radical extension of lifespan would require complex interventions, and studies of animals with drastically slowed aging would not help us in our search for a truly effective anti-aging therapy," explains Peter Fedichev, the principal investigator of the Gero/Skoltech/MIPT group.

"This study resulted in several practical implications for aging research and the growing longevity industry. Firstly, we demonstrated that aging in nematodes is partially programmed and can be modified therapeutically. This might well hold true for other multicellular organisms, humans included. Secondly, we proposed a new method of searching life-extending compounds. The usual procedure involves laborious screening of large libraries of potential drugs. Unfortunately, even successful hits sometimes get missed by chance or due to non-optimal dosage. Our method allows for a targeted search of the compounds with the required activity, including FDA-approved drugs. The latter compounds have the advantage that they have already passed all the necessary clinical trials and can be used off-label as anti-aging drugs," said Andrei Tarkhov, Gero research scientist and a Ph.D. candidate at Skolkovo Institute of Science and Technology.

Source:

 

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JUN 15, 2019
Drug Discovery
JUN 15, 2019
Nicotine on Human Embryonic Development
Researchers report in a study published in the journal Stem Cell Reports, that nicotine exerted adverse effects on human embryonic development at the cellu...
JUN 15, 2019
Drug Discovery
JUN 15, 2019
Combination Immunotherapy Stops Liver Cancer Growth
The number of individuals diagnosed with liver cancer is on the rise and current therapies are largely ineffective. However, new preclinical data from the ...
JUN 15, 2019
Drug Discovery
JUN 15, 2019
Drug Combination for Pediatric Low-grade Glioma
Scientists at the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a new drug combination treatment ta...
JUN 15, 2019
Health & Medicine
JUN 15, 2019
Pain is biologically different for women and men: drugs could be too
Women and men have biologically different pathways for chronic pain. Research published in the journal Brain revealed that different genes and pain si...
JUN 15, 2019
Drug Discovery
JUN 15, 2019
Glowing Tumors Reveal How Immunotherapeutics Work
In a study published in the Journal of Clinical Investigation, researchers used positron emission tomography (PET) scans to examine how an immunotherapy dr...
JUN 15, 2019
Drug Discovery
JUN 15, 2019
Novel Strategy for Drug Discovery and Development
Researchers at Dartmouth College have developed a novel strategy for drug discovery and development such development can be used to target new therapies ag...
Loading Comments...