JUN 06, 2019 11:28 AM PDT

Anti-Hypertensive Drug Use and Dementia?

WRITTEN BY: Nouran Amin

A soon to be published study investigated the relationship between antihypertensive drug use and dementia in older adults. The study derived data from the Disease Analyzer database (IQVIA) which compiled drug prescriptions, diagnoses, and basic medical and demographic data obtained anonymously from computer systems utilized by general practitioners and specialists.

Learn more about IQVIA integrated technologies:

Using three logistical regression model, the association between the use of antihypertensive drugs and dementia incidence was observed after adjustments to blood pressure.

"After another setback for the anti-amyloid strategy, dementia prevention is increasingly becoming an area of interest," explains Dr. Jens Bohlken, MD, PhD, from the Institute of Social Medicine, Occupational Health and Public Health (ISAP) from the Medical Faculty of the University of Leipzig. "In view of this, our most important task is to find existing therapies that are associated with a reduction in dementia risk or at least an extension of the time to dementia onset."

The main conclusion of the research was that dementia is a function of the use of antihypertensive drugs (i.e. diuretics, beta blockers, calcium channel blockers, angiotensin-converting enzyme [ACE] inhibitors, and angiotensin II receptor blockers).

"Antihypertensive therapy alone cannot guarantee that dementia will never occur," noted corresponding author Prof. Karel Kostev, PhD, from the Epidemiology Department of IQVIA (Germany), "However, these findings highlight the importance of the prescription of antihypertensive drugs in the context of preventing hypertension-associated cognitive decline."

The use of angiotensin II receptor blockers, calcium channel blockers, and beta blockers were associated with a decrease in dementia incidence and for patients treated with higher doses of calcium channel blockers, decreased dementia was more evident. Authors of the study also notes that, "further studies are needed to gain a better understanding of the medications associated with a decreased risk of dementia. We plan to investigate the role of lipid-lowering drugs, antidepressants, and further medications in the future."

Source: Science Daily

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
AUG 19, 2019
Drug Discovery
AUG 19, 2019
Long-Lasting Worms Inspires Anti-Aging Drugs
Researchers have recently discovered that aging in nematodes may be partially controlled and can be therapeutically reversed through multiple FDA-approved ...
AUG 19, 2019
Microbiology
AUG 19, 2019
Manuka Honey Kills Cystic Fibrosis Pathogens in Culture
Manuka honey is recognized as a natural antimicrobial agent, and has been used in folk medicines for thousands of years....
AUG 19, 2019
Genetics & Genomics
AUG 19, 2019
Clinical Trials Aim to Improve Therapeutics with Genomic Data
Scientists now have access to vast amounts of human genetic data. Now the NIH wants to put that data to use....
AUG 19, 2019
Health & Medicine
AUG 19, 2019
Remember Joe Camel? E-cigarette cartoon ads increase the chances of vaping
Do you remember the infamous "Joe Camel" advertisements for cigarettes back in the 1980s and 90s? These ads successfully got a generation of youn...
AUG 19, 2019
Clinical & Molecular DX
AUG 19, 2019
Possible Non-Hormonal Treatment For Endometriosis On Horizon
With over 200,000 cases reported annually, endometriosis is a big concern in women’s health. Scientists don’t yet know what causes the painful ...
AUG 19, 2019
Drug Discovery
AUG 19, 2019
Novel Therapy Shows Promise for Acute Migraines
In a study published in The New England Journal of Medicine, a novel drug, by the name of rimegepant, was found to eliminate pain and reduce characteristic...
Loading Comments...