AUG 01, 2019 11:08 AM PDT

Aspirin Usage Improves Liver Function After Embolization Treatment

WRITTEN BY: Nouran Amin

Aspirin usage has been under scrutiny in recent research. But now, studies are bringing aspirin therapy in renewed light with its association in improving liver function after an embolization procedure. In a study published in the American Journal of Roentgenology (AJR),

The therapeutic use of appropriate doses of aspirin improved the function and survival of the liver in patients who had hepatocellular carcinoma (HCC) after transarterial embolization (TAE).

Learn more about transarterial embolization (TAE):

In a retrospective review study involving 304 patients led by F. Edward Boas at Memorial Sloan Kettering Cancer Center in New York City, 42 patients were found to be taking aspirin at the time of the TAE procedure for HCC treatment. This was evident by the bilirubin levels: lower 1 day (0.9 vs 1.3, p < 0.001), 1 month (0.9 vs 1.2, p = 0.048), and 1 year (0.8 vs 1.0, p = 0.021) post-embolization.

"Although the differences in liver function test results in the groups taking and not taking aspirin were small, standard biochemical liver function tests are insensitive to early cirrhotic changes,” says Boas before clarifying further that "small changes in biochemical liver function test results might underestimate the degree of liver injury after embolization."

The usage of aspirin therapy had no indications of disparities in an initial response rate--(88% vs 90% complete response or partial response, p = 0.59), median time to progression (6.2 vs 5.2 months, p = 0.42), initial site of progression (p = 0.77)--or disparities in the fraction of patients dying with HCC progression (88% vs 89%, p = 1.00). Overall, median HCC survival after TAE procedure was measured longer for the cohorts on aspirin therapy(57 vs 23 months, p = 0.008).

Because the study was a retrospective analysis, there may be confounding variables that account for the improved survival among TAE treated HCC patients who took aspirin. Such clinical characteristics of the results, and despite the comparable liver function, more research is needed to ensure how effective and safe aspirin therapy may be in future treatments.

Source: American Roentgen Ray Society

About the Author
  • Nouran enjoys writing on various topics including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
SEP 18, 2019
Cell & Molecular Biology
SEP 18, 2019
Scientists Discover Why Arteries Harden & Find a Potential Treatment
As we get older, our arteries slowly begin to stiffen and then harden, which can lead to many serious complications. Now there may be a way to treat it....
SEP 18, 2019
Drug Discovery
SEP 18, 2019
Anticholinergic Drugs and Dementia?
A link between anticholinergic drug use and cognitive impairment was recently observed from observational studies on randomized clinical trials. Regenstrie...
SEP 18, 2019
Drug Discovery
SEP 18, 2019
Controlling The Release of Drug Components Using Artificial DNA
Studies carried out at the Technical University of Munich (TUM) can allow nanapoarticles to be released in pre-defined sequence at specified times. Using a...
SEP 18, 2019
Drug Discovery
SEP 18, 2019
Chemotherapeutics react differently to radiation
Patients with various types of cancer are almost always treated with a combination of chemotherapy and radiotherapy. In chemotherapy, therapeutics consist ...
SEP 18, 2019
Drug Discovery
SEP 18, 2019
Can FDA Approved Ketamine Drug Spravato Really Treat Depression?
President Trump is allegedly in support of a new drug to combat depression. He even urged the Department of Veterans Affairs to purchase it and “get ...
SEP 18, 2019
Cancer
SEP 18, 2019
Cancer drugs don't work the way we thought
New research recently published in the journal Science Translational Medicine surprises the oncological community with findings that a protein previously t...
Loading Comments...