NOV 22, 2017 01:59 PM PST

Bi-Specific Antibodies- New Improvements to Cancer Immunotherapy

In the last several years, immunotherapy has been hailed as the therapeutic breakthrough for cancer that we’ve all been waiting for.  The ability to utilize and manipulate our own immune systems to eradicate cancer is not only highly promising, but has already proven effective in a subset of patients in the clinic – and this is not just in one cancer type – but many.  A lot of attention has been given to immune checkpoint blockade in highly mutagenic cancers such as melanoma and those of the lung, as well as to chimeric antigen receptor T-cell therapy (CAR-T therapy), but a third category is now gaining more attention as well.  This category is that of bispecific antibodies, or BsAbs.   Interestingly, bispecific antibodies were originally hypothesized to be a method to combat cancer as early as the 1980s.  These work through their affinity to two different targets which act to promote tumor progression.  By binding these targets, they in essence block their ability to interact with their normal partners and are then unable exert their oncogenic effects.  They also have the ability to link therapeutic agents to cancer cells to deliver the desired blow of the therapies.  This video, published by Roche in May of 2016, details the use of T-cell bispecific antibodies for use in cancer.

Sources: Roche, Youtube, Nature Reviews

 

 

 

 

About the Author
You May Also Like
JUL 24, 2018
Drug Discovery
JUL 24, 2018
Therapeutic Target For Kidney Cancers
Researchers at Lineberger Comprehensive Cancer Center in University of North Carolina revealed a therapeutic target for kidney cancers that share a common ...
JUL 31, 2018
Drug Discovery
JUL 31, 2018
Pill Approved For Endometriosis Treatment
A first drug, by the name of Elagolix, to treat for endometriosis-related pain, has recently become approved by the US Food and Drug Administration. Endome...
SEP 24, 2018
Drug Discovery
SEP 24, 2018
Further Challenges in Alzheimer Drug Development
Scientists at Trinity College Dublin performed a large-scale international study involving the treatment of Alzheimer's disease, which was published in...
OCT 06, 2018
Drug Discovery
OCT 06, 2018
New Class of Drugs for Breast Cancer Therapy
Scientists at Stevens Institute of Technology have designed a new class of molecules that may hold the potential to add to the arsenal of drugs actively be...
OCT 31, 2018
Cancer
OCT 31, 2018
Researchers identify a protein marker that induces dormancy in metastatic breast cancer
Researchers at the Mount Sinai hospital identified for the first time a protein marker that could indicate whether breast cancer will further metastasize or remains in a dormant state accordi...
NOV 05, 2018
Microbiology
NOV 05, 2018
Potential Antidote to Botulism is Found
A microbe called Clostridium botulinum and sometimes two other strains of Clostridium bacteria can make a toxic chemical called botulism....
Loading Comments...