Dharmacon continues to be the industry leader in the field of RNA chemistry, RNAi biology and high-throughput screening, and partners with the RNAi screening community through participation in the RNAi Global Initiative. With Dharmacon, you get access to the largest and most complete portfolio of innovative and technologically advanced tools for gene silencing, gene expression and gene editing. Our solutions include: siRNA: Patented dual-strand modifications provide unrivaled specificity and potency; Accell® siRNA is the only siRNA reagent that can be delivered to difficult-to-transfect cells WITHOUT a transfection reagent; Lincode siRNA for efficient knockdown of long, noncoding RNA (lncRNA) genes. shRNA: microRNA-adapted shRNA for transient, constitutive and inducible RNAi provide specific and potent, long-term silencing with a choice of promoters for optimal expression in a variety of cell types. microRNA: Up-regulate or suppress endogenous microRNA function with microRNA mimics and hairpin inhibitors. cDNAs and ORFs: From genome-scale libraries to individual clones, Dharmacon has one of the largest clone collections. Custom RNA synthesis: Trust the experts in RNA synthesis chemistry to provide high-quality custom single-stranded RNA, siRNA, and microRNA with an extensive range of modifications, synthesis scales, and purification choices. RNAi screening libraries: Choose from our siRNA, shRNA and microRNA libraries for small gene families to genome-wide collections, or make your own library with our Cherry-Pick libraries - you select the gene targets, products and quantities. Gene editing: A broadly applicable, simplified platform for gene editing in mammalian cells based on the CRISPR-Cas9 system.