MENU
JAN 31, 2018 8:00 AM PST

High Content Screening-Based Phenotypic Analysis Of Organotypic 3D Bronchial Tissues

Sponsored by: Thermo Fisher Scientific
Speaker
  • High Content Screening Manager, System Toxicology , Philip Morris International R&D
    Biography
      Diego Marescotti is the High Content Screening Manager in the System Toxicology department of Philip Morris International R&D. After completing his PhD in Oncology and Molecular Pharmacology, at the University of Ferrara (Italy) he continued his research investigating the mechanism of tumor escape from immune surveillance. As a scientist he joined Philip Morris International in 2012 bringing his knowledge and interest for flow cytometry and imaging. He is now leading a team of researchers which operate a high-throughput system for compound profiling.

    Abstract

    One of the goals of the “3Rs principle” is to replace in vivo testing methodologies with in vitro procedures on human cells, followed by computational systems biology modelling to determine toxicological risk. System toxicology, which integrates standard toxicology together with quantitative analysis of large networks of molecular and functional changes, have demonstrated the potential to help realize the 3Rs vision. Omics and high content screening methods represent fundamental pillars of a system toxicology-based approach and at Philip Morris International R&D we have developed a large battery of HCS assays to investigate how specific substances alter the phenotype of a cell grown in submerged conditions. As more physiological cell culture model, such as organotypic 3D culture are also part of our portfolio, we invested in the development of imaging-based approaches which would enable high-content investigations of 3D bronchial tissues. In this seminar, recently developed approach for phenotypic analysis of organotypic 3D Bronchial Tissues will be presented.


    Show Resources
    You May Also Like
    JAN 23, 2020 9:00 AM PST
    C.E. CREDITS
    JAN 23, 2020 9:00 AM PST
    DATE: January 23, 2020 TIME: 9:00am PST, 12:00pm EST...
    APR 07, 2020 8:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    APR 07, 2020 8:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: April 7, 2020 TIME: 8:00am PT, 11:00am ET This webinar sets out to establish why quality control is key to robust, reliable, reproducible science. We will look at best practice criteri...
    FEB 26, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 26, 2020 9:00 AM PST
    DATE: February 26, 2020 TIME: 9:00am PST 3D cell culture and analysis and the study of organoids and spheroids are becoming more prevalent as a research method in publications as traditional...
    MAY 08, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    MAY 08, 2020 10:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    DATE: May 8, 2020 TIME: 10:00am PT, 11:00am MT, 1:00pm ET The application of next generation sequencing to interrogate immune repertoires and methods in which these highly complex dataset...
    MAR 03, 2020 9:00 AM JST
    C.E. CREDITS
    MAR 03, 2020 9:00 AM JST
    DATE: March 3, 2020 TIME: 9:00am JST A major limitation in the ex vivo expansion of harvested human hematopoietic stem-progenitor cells (HSPCs) is the rapid differentiation of HSPCs at the e...
    FEB 25, 2020 9:00 AM PST
    C.E. CREDITS
    FEB 25, 2020 9:00 AM PST
    Learn about how to generate a small scale CAR-T workflow using ThermoFisher products See detailed characterization tools that can be utilized and applied in a CAR-T workflow...
    Loading Comments...
    Show Resources