APR 28, 2021 9:00 AM PDT

Physiologic medium to study human cell biology

Speaker
  • Investigator, Morgridge Institute for Research, Assistant Professor of Biochemistry, University of Wisconsin-Madison
    Biography

      Jason earned his B.S. magna cum laude in Chemical Engineering from Cornell University and then completed his Ph.D. in Chemical Engineering from The University of Texas at Austin. Under the guidance of George Georgiou, Jason's doctoral work focused on developing new strategies to engineer anti-cancer therapeutic enzymes with reduced immunogenicity and was supported in part by a graduate fellowship from the US Department of Homeland Security. Jason then completed his postdoctoral training in the laboratory of David M. Sabatini at the Whitehead Institute/MIT. During that time, his work focused on investigating how environmental factors impact cancer metabolism and involved creating the first systematically designed physiologic medium (human plasma-like medium; HPLM) among other new tools. This work was supported in part by fellowships from both the American Cancer Society and the Koch Institute for Integrative Cancer Research at MIT. Jason then launched his independent program as an Investigator at the Morgridge Institute for Research with joint appointment as an Assistant Professor of Biochemistry (with affiliate status in Biomedical Engineering) at the University of Wisconsin-Madison and membership in the Carbone Cancer Center. Thermo Fisher Scientific is proud to work with Jason and David in bringing HPLM to market, and excited by the immense possibilities that it could bring to diverse areas of the scientific community. Jason and David are inventors on a patent application for HPLM assigned to Whitehead Institute.


    Abstract

    DATE:  April 28, 2021

    TIME:  9:00am PDT, 12:00pm EDT

     

    Environmental factors influence human cell physiology and can also affect drug efficacy, but existing model systems used to study human cells have limitations for understanding these contributions. In this webinar, Dr. Jason Cantor will discuss the initial development and use of human plasma-like medium (HPLM), a physiologic medium designed to more closely reflect the metabolic composition of human blood. By examining human cancer cell lines in HPLM versus traditional media, Dr. Cantor and colleagues have recently shown that HPLM has widespread effects on metabolism and gene essentiality, and further, that HPLM can be used to reveal new insights into metabolic regulation and drug efficacy.

     

    Learning Objectives:

    • Complete media that remain the workhorses of cell culture studies typically consist of a basal medium that poorly resembles conditions encountered in the human body and a largely undefined serum supplement

    • Human Plasma-Like Medium (HPLM) is a relatively new physiologic basal medium designed to more closely reflect the metabolic composition of human blood

    • The development of physiologic media, like other efforts designed to address the modeling capacity of cell culture, holds immense potential to improve understanding and interpretation of biological and pharmacological studies

     

     

     

    Webinars will be available for unlimited on-demand viewing after live event.


    Show Resources
    You May Also Like
    MAY 11, 2021 10:00 AM PDT
    C.E. CREDITS
    MAY 11, 2021 10:00 AM PDT
    Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    C.E. CREDITS
    JUN 09, 2021 7:00 AM PDT
    Add to Calendar Select one of the following: iCal Google Calendar Outlook Calendar Yahoo Calendar
    Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
    DEC 02, 2020 8:00 AM PST
    C.E. CREDITS
    DEC 02, 2020 8:00 AM PST
    DATE: December 2nd, 2020 TIME: 08:00am PDT, 11:00pm EDT Bioreactors and shakers are used to cultivate microorganisms, plant, insect, and mammalian cells in different volumes. Upscaling of pr...
    NOV 18, 2020 8:00 AM PST
    C.E. CREDITS
    NOV 18, 2020 8:00 AM PST
    DATE: November 18, 2020 TIME: 08:00am PDT We develop and implement technologies to solve some of the major bottlenecks in biomedical research. In particular, we establish new imaging approac...
    APR 01, 2021 8:00 AM PDT
    C.E. CREDITS
    APR 01, 2021 8:00 AM PDT
    Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
    MAR 16, 2021 10:00 AM PDT
    C.E. CREDITS
    MAR 16, 2021 10:00 AM PDT
    Date: March 16, 2021 Time: 10:00am (PST) Scientific progress and breakthroughs today are often too expensive for most institutions to acquire. Each year, the National Institutes of Health (N...
    Loading Comments...
    Show Resources
    Attendees
    • See more