APR 28, 2021 9:00 AM PDT

Physiologic medium to study human cell biology

Speaker
  • Investigator, Morgridge Institute for Research, Assistant Professor of Biochemistry, University of Wisconsin-Madison
    BIOGRAPHY

Abstract

DATE:  April 28, 2021

TIME:  9:00am PDT, 12:00pm EDT

 

Environmental factors influence human cell physiology and can also affect drug efficacy, but existing model systems used to study human cells have limitations for understanding these contributions. In this webinar, Dr. Jason Cantor will discuss the initial development and use of human plasma-like medium (HPLM), a physiologic medium designed to more closely reflect the metabolic composition of human blood. By examining human cancer cell lines in HPLM versus traditional media, Dr. Cantor and colleagues have recently shown that HPLM has widespread effects on metabolism and gene essentiality, and further, that HPLM can be used to reveal new insights into metabolic regulation and drug efficacy.

 

Learning Objectives:

  • Complete media that remain the workhorses of cell culture studies typically consist of a basal medium that poorly resembles conditions encountered in the human body and a largely undefined serum supplement

  • Human Plasma-Like Medium (HPLM) is a relatively new physiologic basal medium designed to more closely reflect the metabolic composition of human blood

  • The development of physiologic media, like other efforts designed to address the modeling capacity of cell culture, holds immense potential to improve understanding and interpretation of biological and pharmacological studies

 

 

 

Webinars will be available for unlimited on-demand viewing after live event.


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