Discover how mass photometry (MP) streamlines antibody discovery and development workflows by enabling rapid, label-free, single-particle mass measurements under native conditions with minimal sample requirements. MP offers a powerful solution to:

• Measure antibody aggregation column-free without method development
• Reduce time and sample consumption – measurements take a minute and only use nanograms
• Identify high affinity binders and determine stoichiometry of binding – needed to distinguish between avidity vs affinity
• Inform on assembly mechanism and cooperativity at physiological concentrations

Learning Objectives:

1. Learn the principles of mass photometry and its operation as an analytical technique.

2. Understand how mass photometry can serve as a columnfree complement to SEC for evaluating antibody aggregation.

3. Learn how bindingstoichiometry measurements provide insight into cooperativity, avidity, and affinity in antibody interaction studies.