MAY 25, 2017 12:00 PM PDT

Automated Pathology Robotics and Informatics Across the Top

Presented at: Lab Automation 2017
  • Founder and CEO of 3Scan
      Todd Huffman is the CEO of 3Scan, and has been working with the technology behind 3Scan since 2005. Todd Huffman worked with the late Bruce McCormick, who pioneered the KESM technology. Dr. McCormick saw connectomics and meso-scale neural architecture as a key to understanding human computation. Fearing that the technology would languish after the death of Dr. McCormick, Todd decided to develop 3Scan Corp to enable its continued development. While working on his MS in bioinformatics he collaborated with at Texas A&M, and architected the spin out of 3Scan into a commercial enterprise.


    Diseases like cancer have complex tissue morphology requiring microscopic examination.  Typically this involves 2D examination through a microscope by a pathologist, a slow and manual process and doesn't reveal 3D structures.  3D serial section microscopy has proven to be a powerful tool in examining the 3-dimensional nature of tissue; however, it is limited by the size of tissue samples that can be used and the manual process of acquiring data.

    The Knife-Edge Scanning Microscope (KESM) acquisition and analysis computational system resolves these issues by providing high resolution light microscopy image data at multi-cubic centimeter scale. Using this system for quantification of microvasculature provides the ability to examine, measure, and compare the 3-dimensional nature of vascular networks at whole organ scale and sub-micron resolution.

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