Produced by 
MAR 16, 2017 09:00 AM PDT
Capturing cocaine memories in the perineuronal net
Presented at the Neuroscience 2017 Virtual Event
1 1 21

  • Professor of Neuroscience, Washington State University, Vancouver
      Barbara A. Sorg, Professor, received her B.S. in biology in 1981 from Ball State University. In 1987, she earned her Ph.D. in biochemistry from the University of Maryland. Dr. Sorg has been in the Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology at Washington State University since 1990. Dr. Sorg is also the Director of the WSU Alcohol and Drug Abuse Program


    Specialized aggregations of extracellular matrix called perineuronal nets (PNNs) appear during juvenile stages of development and surround primarily fast-spiking, parvalbumin (PV)-containing GABAergic interneurons in the central nervous system. These PNNs are an exciting structure to explore in drug abuse research because previous studies show that removing them in certain brain regions re-establishes juvenile-like states of plasticity; therefore, we may be able to alter the brain plasticity imposed by drugs of abuse. Our studies in rats show that removal of PNNs within the prelimbic region of the medial prefrontal cortex (mPFC) impairs the consolidation and reconsolidation of cocaine-associated memories in a cocaine-induced conditioned place preference (CPP) task. In addition, removal of PNNs blunts the acquisition of cocaine self-administration and appears to blunt the reconsolidation of the memory associated with cocaine cues. Conversely, cocaine exposure alters the intensity (thickness) of PNNs and the intensity of PV cells in the prelimbic mPFC. While acute cocaine injection decreases the intensity of PNNs and PV cells, repeated cocaine injection increases the intensity of PNNs and PV cells. Some of these changes observed after cocaine may be mediated by oxidative stress. Overall, our studies suggest that PNNs within the mPFC are highly dynamic and modulate cocaine-induced plasticity.

    Show Resources
    Show Resources