MAY 13, 2020 8:00 AM PDT
Coronavirus Disease 2019 (COVID-19): Role of Serologic Testing in Diagnosis and Assessment of Viral Immunity
David M. Engman, MD, PhD
Chairman Emeritus of Pathology, Cedars Sinai Medical Center - Clinical Professor of Pathology, UCLA - Adjunct Professor of Pathology, Northwestern University
Provide education on COVID-19 disease and SARS-CoV-2.
Review the types of tests used for the diagnosis of infectious diseases.
Discuss approaches to serologic test development.
Review the kinetics of the antibody response and the functions of immunoglobulin subclasses in the immune response and analytes for monitoring immunity to a pathogen (SARS-CoV-2)
Discuss pros and cons in measuring virus-specific IgG vs IgG+IgM.
Discuss the functions of the SARS-CoV-2 proteins commonly employed in serologic assays—Nucleocapsid Protein and Spike Protein.
Review the differences and similarities of diagnostic antibodies and neutralizing antibodies.
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