APR 28, 2017 6:00 AM PDT

Disseminated Intravascular Coagulation (DIC) and Thrombosis: The Critical Role of the Lab

Sponsored by: Diagnostica Stago, Inc.
  • Scientific Business Development Manager, Diagnostica Stago, Inc.
      Paul earned a PhD in biochemistry from Temple University in 2006, with the subject of the dissertation regarding the function of coagulation factor XI. He also did postdoctoral training in a related area before becoming a product manager and scientific affairs specialist in 2009. During his time at Stago, Paul also completed an MBA degree program at Cornell University in 2014. He has spoken to dozens of medical technologist, clinical laboratory scientist, pharmacist and clinician audiences about various topics within hemostasis and coagulation. He also has a great interest in working with clinical pathologists, pharmacists, basic scientists, and pharmaceutical researchers to perform studies and publish, contributing to advancement of the hemostasis and coagulation science.


    Disseminated Intravascular Coagulation (DIC) is a serious hypercoagulable disorder which can occur in hospitalized patients resulting in a high degree of morbidity and mortality.  DIC is a confusing disorder from both diagnostic and therapeutic standpoints resulting from several unrelated diseases which can trigger DIC, along with a lack of uniformity in clinical manifestation, laboratory diagnostic practices, and consensus on patient management.  The laboratory, by implementing the correct panel of testing methodologies, can greatly assist clinicians in patient management.  This lecture will describe the laboratory testing in order to illuminate this condition for people unfamiliar with the condition.

    Learning objectives:

    1. Describe the basic pathophysiology of DIC
    2. Demonstrate a diagnostic and management approach for DIC
    3. Compare markers of thrombin & plasmin generation in DIC, including D-Dimer, Fibrin Monomers/soluble fibrin, and fibrin degradation products (FDPs)
    4. Correlate DIC theory and testing to specific clinical case


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