Infertility affects one in six couples, with fertility treatments facing daunting 2:1 odds of failure versus success. Emerging research highlights the critical role of vaginal microbiome health in reproductive outcomes. Dysbiosis and other microbiological conditions of the female genitourinary system have been strongly linked to poor fertility outcomes. However, routine infertility care is hindered by the lack of standardized diagnostic tools for microbiome characterization. Current standard of care tests are not suitable for microbiome profiling, and common approaches for microbiome analysis, such as sequencing, face significant technical limitations when applied to vaginal specimens.

This presentation reviews key studies connecting vaginal microbiome health to fertility outcomes and examines the technical barriers to vaginal microbiome analysis. It introduces PMP™, a precision microbiome profiling method utilizing highly parallelized single-plex quantitative PCR, and discusses its potential for routine use in infertility care, including applications in blended care models.