Antimicrobial resistance (AMR) represents one of the most pressing global health challenges of the 21st century, threatening the effectiveness of treatments and burdening healthcare systems worldwide. Traditional diagnostic methods, while foundational, often result in delays that contribute to the empirical and sometimes inappropriate use of broad-spectrum antibiotics. Advances in molecular diagnostics now offer unprecedented speed and accuracy in identifying infectious pathogens and resistance markers. However, the full potential of these technologies is realized only when integrated thoughtfully into clinical workflows. Clinical Decision Support (CDS) software serves as a critical bridge between complex molecular data and real-time, evidence-based clinical decision-making. By providing clinicians with rapid, actionable insights, CDS systems enhance the stewardship of antimicrobials, reduce unnecessary antibiotic exposure, and improve patient outcomes. This session will explore how molecular diagnostics, when paired with sophisticated CDS tools, can transform antimicrobial stewardship efforts, while also addressing current limitations and future directions.