Interference in laboratory assays is a concern since it can positively or negatively influence test results, which can affect patient care. Interferents could be endogenous or exogenous compounds. Dietary supplements such as biotin and vitamin C are examples of exogenous interferents in common laboratory assays. During this presentation, mechanisms underlying such interference will be discussed, along with ways of detecting it and possible solutions.

Learning Objectives:

1. Outline an overview of analytical interferences in laboratory assays.

2. Describe potential interference caused by megadose biotin and vitamin C supplementation.

3. Discuss strategies to detect and mitigate such interferences.