Date: December 4, 2020

Time: 9:00am PST, 12:00pm EST

Activation of Myeloid cells and interferon release is an early response to infection. The 3-marker combination (CD169/CD64/HLA-DR) gives an excellent overview of the innate immune response. The flow cytometry assay can effectively differentiate the immune response to bacteria or viruses.
Bacterial stimuli: CD64 overexpression on neutrophils (nCD64).
Viral stimuli: CD169 overexpression on monocytes (mCD169).
Recent stimulus: increased HLA-DR, Overstimulation/Immune exhaustion: decreased HLA-DR.
Further, the assay, using whole blood, is rapid and easy to perform, making this an invaluable tool in clinical research on antibiotic resistance, and studying interferon signaling during infections.

 
Learning Objectives:

• Describe Myeloid cell activation and how it is specific for viral and bacterial infections due to differential interferon signaling.
• Explain how Markers CD64 and CD169 can be effectively used to differentiate between the types of infections.

* For Research Use Only. Not for use in diagnostic procedures.

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