OCT 12, 2017 1:30 PM PDT

Metabolic Regulation of Cell Fate Decisions

Sponsored by: Agilent
  • Assistant Member, Cell Biology Department, Memorial Sloan Kettering Cancer Center
      Lydia Finley is an Assistant Member in the Cell Biology Program at Memorial Sloan Kettering Cancer Center. Dr. Finley received her BS from Yale University and then completed her PhD in the laboratory of Dr. Marcia Haigis at Harvard Medical School. As a postdoctoral fellow in the laboratory of Dr. Craig Thompson at Memorial Sloan Kettering Cancer Center, Dr. Finley identified metabolites that contribute to the regulation of stem cell self-renewal. Her current work investigates the mechanisms that link metabolic pathways to cell fate decisions. She is the recipient of the Jack Sorrell Fellowship of the Damon Runyon Cancer Research Foundation and the Dale F. Frey Award for Breakthrough Scientists.


    The deposition and removal of DNA and histone modifications depends on the availability of specific metabolites, suggesting that cellular metabolic pathways may dynamically regulate chromatin modifications and gene expression. However, whether changes in metabolic flux can influence cell fate decisions is poorly understood. Dr. Finley’s research focuses on understanding how cell type-specific metabolic profiles contribute to the establishment and regulation of cell identity. In her seminar, Dr. Finley will present recent work illustrating how the metabolic wiring of embryonic stem cells promotes an open chromatin landscape and the maintenance of pluripotency. These results reveal that intracellular metabolic pathways play a mechanistic role in the transcriptional and epigenetic state of stem cells.

    For Research Use Only. Not for use in diagnostic procedures.

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