There is a growing debate about the usefulness of animal studies in biomedical research and drug development. Some of the challenges in translation from animals to human patients may be from weaknesses in how we conduct those studies. Technological advancements are providing opportunities to expand the data we collect from animals and improve alignment to clinical data and data management. Areas of potential 3Rs impact include environmental monitoring and controls, physiological monitoring, behavioral monitoring and assessments and data management. Technologies are providing innovative approaches to determining optimal housing conditions, improved animal study reproducibility, physiologic and translationally relevant data collection and ability to iteratively learn from studies in perpetuity. The overall impact of these capabilities when integrated in meaningful ways could reduce animal use, reduce pain and discomfort and improve clinical predictivty. Participants will learn about various technological advances enabling 3Rs impact and potentially improved clinical predictivity. In addition, participants will learn about the gaps with current approaches in these areas and how new and future technological capabilities can be leveraged to improve the welfare and scientific impact and relevance of animal studies.