The COVID-19 pandemic has had a broad and significant impact on society, affecting nearly all aspects of Healthcare, with huge increases in direct and indirect medical costs, fundamental changes in healthcare delivery models, and impulse for clinical research to attenuate disease symptoms and/or discover prophylactic measures against the virus. Self-isolation, research site closures, travel limitations, interruptions to the supply chain for the investigational product have impacted clinical trials, although pragmatic and impactful solutions to address the challenges/disruptions have been put in place. A broad overview of the drug development during the pandemic will be given, encompassing clinical trials conduct and quest for new therapies.