MAY 29, 2015 8:00 AM PDT

The Role of Thrombin Time in the Clinical Laboratory

Sponsored by: Diagnostica Stago, Inc.
  • QA Manager for Specialty Testing Supervisor, Special Coagulation and Hematology, New York Presbyterian Hospital
      Donna is Quality Assurance (QA) Manager, Specialty Testing Supervisor, Special Coagulation and Special Hematology at New York Presbyterian Hospital- Columbia in New York City. She has 34 years clinical laboratory experience, 6 years industry clinical trial experience, including PhD work on Standardization of Laboratory Testing (all but dissertation). Donna has written several book chapters, many publications and presented many coagulation lectures to diverse audiences at all levels of expertise. She is adjunct professor at York College and Rutgers University. Donna presently serves on the Executive Committee of the North American Specialized Coagulation Laboratory Association (NASCOLA) as a Secretary, Publication Committee and Pre-Curriculum Committee for the American Society for Clinical Pathology (ASCP), and the Expert Committee for Hematology for the Clinical Laboratory Standards Institute (CLSI). She is also a member of International Society on Thrombosis and Haemostasis (ISTH), International Society for Laboratory Hematology (ISLH) and ASCP.


    The thrombin time assay is a versatile clinical assay used for screening fibrinogen related disorders and quantification of fibrin degradation products, as well as for detecting the presence of anticoagulant drugs.  In situations where other screening tests may not be used to reliably diagnose fibrinogen related disorders, use of the thrombin time to discriminate these disorders may be the most effective choice.  With new classes of direct oral anticoagulants in clinical use, interest in the thrombin time has increased.  The purpose of this program is to describe the methodology and optimal use of the thrombin time assay for regular use in the clinical laboratory.  Case studies highlighting the various applications of the thrombin time will also be presented.

    • Describe the mechanism of the Thrombin Time assay.
    • Identify how to optimize utilization of the Thrombin Time in the laboratory.
    • Analyze results to enhance problem solving.

    Show Resources
    Show Resources
    • See more