Spatial omics technologies use imaging methods to acquire localized molecular readouts. While powerful, these technologies pose many challenges. The field requires sophisticated computational infrastructure, novel analytical methods, and innovative approaches in order to realize its full potential. Combined with high-content screens, these applications will reveal the impact of perturbations on biological scales, such as tissues and organ systems, as never before possible. This session will highlight emerging solutions to increase information content of spatial omics data that will power the ultra-high-content screens of the future.