Explore the transformative role of three-dimensional (3D) cell models, like organoids and spheroids, in advancing medicine. These models provide a more physiologically relevant environment than traditional two-dimensional (2D) cultures, offering crucial insights into disease understanding and targeted treatment development. However, the complexity of 3D models requires innovative solutions to maintain their integrity and viability. High-throughput processing is essential for efficiently generating and analyzing large volumes of data, with life science instrument technology companies developing solutions to meet these demands.
Advancements include live-cell imaging platforms like Incucyte® Live-Cell Analysis, enabling continuous monitoring of 3D cultures without disturbing cellular biology, and providing real-time insights into gene expression and cell behavior. Automated systems such as Incucyte and CellCelector Flex facilitate high-throughput workflows, maintaining the viability and integrity of delicate structures like induced pluripotent stem cells (iPSCs) and organoids.
The eBook highlights the importance of standardized workflows for high-throughput cell manipulation and analysis, featuring application notes on culturing, maintaining, and characterizing iPSCs, as well as label-free, real-time live cell assays for 3D organoids. These technologies enhance the reproducibility, efficiency, and physiological relevance of 3D cell models, accelerating breakthroughs in precision medicine and translational research.