AUG 08, 2025

Analytical Ultracentrifugation (AUC) for Characterization of Lipid Nanoparticles (LNPs): A Comprehensive Review

WRITTEN BY: Sarah Hoffman

Lipid nanoparticles (LNPs) and liposomes (Figure 1) have revolutionized the medical field by serving as carriers for a wide range of therapeutic molecules, and have been used for cancer treatments, drug delivery, and vaccine development, including the recent COVID-19 mRNA vaccines by Moderna and Pfizer-BioNTech. mRNA cannot be injected directly into a patient due to its immunogenicity, toxicity, and susceptibility to RNase degradation and renal clearance;1 however, by packaging the RNA into LNPs, these issues can be overcome. LNPs offer additional advantages, such as improved stability, targeted delivery, and adaptability to changing viral strains.2

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