A clinical trial published in JAMA Psychiatry examined the effects of high-intensity interval training (HIIT) on hippocampal health in chronic cannabis users. Prior studies link cannabis use disorder (CUD) to altered hippocampal integrity. However, the Brain Exercise and Addiction Trial (BEAT) findings indicated that neither HIIT nor SR improved cognitive functioning and mental health.
The Monash University researchers compared the impact of a 12-week HITT intervention (3 times a week, high lactate condition) with 12 weeks of strength and resistance (SR) training (3 times a week, low lactate, active control condition). The researchers designed the HIIT protocol to increase lactate exposure, while the SR protocol aimed to minimize it. Accredited exercise physiologists monitored participants during the 45-minute HIIT and SR interventions. Heart rate monitors worn by participants enabled physiologists to track exercise intensity in real-time and adjust the intensity according to individual participant needs.
The research team randomized the 59 participants into HIIT or SR training. The participants included 47 men (80%) and 12 women (20%) with moderate to severe CUD. Their mean age was 27. 80% of the participants completed the 12-week intervention and attended 80% of the exercise sessions. The participants were allowed to continue chronic cannabis use during the study period.
The researchers analyzed a composite of three magnetic resonance imaging (MRI) measures, including anatomical volume, fractional anisotropy, and N-acetylaspartate to assess hippocampal integrity. The researchers also assessed secondary outcomes, such as cognitive and mental health measures.
This study found that a 12-week HIIT intervention did not positively affect hippocampal health while participants chronically consumed cannabis. The results also suggested that individuals with CUD can use regular physical exercise programs as a strategy to minimize cannabis craving.
Sources: Eureka News Alert, JAMA Psychiatry