Standardization and harmonization of coagulation testing methods have come a long way in the last 3 to 4 decades; however, standardization is imperfect. Laboratory professionals need to recognize the limitations of some of our most commonly used coagulation tests. The INR system has harmonized prothrombin time across methods and platforms for the purpose of monitoring warfarin, but the system does not harmonize very high INR values nor does it harmonize INR values in the setting of liver disease. Many hospital-based laboratories perform a one stage factor VIII assay to support a wide range of clinical indications. In the last decade, important biases have been demonstrated between one stage assays and chromogenic assays when diagnosing hemophilia A patients or monitoring new hemophilia therapies. Finally, quantitative D-dimer assays have excellent negative predictive value to exclude venous thromboembolism. Unfortunately, there is a lack of standardization, and even a lack of a standardized unit of measure. Implementation of D-dimer requires careful attention to both the unit of magnitude and the unit type, especially when using different instrumentation across a laboratory system.
Learning Objectives:
LabRoots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety. CE credits are available for this webinar up to 2 years from the date of the live broadcast
Laboratory Testing
Clinical Diagnostics
Immunology
Clinical Chemistry
Microbiology
Hematology
Infectious Disease
Molecular Diagnostics
Molecular Biology
Biochemistry
Genetics
Diagnostics
Cell Biology
Biotechnology
Cancer Research
North America81%
Asia9%
Europe6%
Africa2%
South America1%
Oceania1%
Website Visitors60%
Email Promotions29%
WAVE Newsletter Promotion8%
Client/Sponsor Promotions1%
Trending Newsletter Promotion1%
Other1%
Medical Laboratory Technician28%
Clinical Laboratory Scientist19%
Lab Management14%
Facility/Department Manager9%
Medical Doctor/Specialist7%
Student4%
QC/QA3%
Educator/Faculty3%
Executive3%
Research Scientist3%
Scientist2%
Pathologist2%
Marketing/Sales1%
Chemist1%
Hospital40%
Clinical Laboratory18%
Academic Institution9%
Medical Center5%
Biotech Company3%
Government2%
Independent Laboratories2%
Medical Device Company2%
Diagnostic Company2%
Medical School1%
Consultant1%
Ambulatory Care1%
Research Institute1%
Non-Profit Organization1%
Other3%