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FEB 07, 2017 06:00 AM PST
Heparin Monitoring: aPTT versus Anti-Xa assay
Presented at the Stago EdVantage Virtual University Virtual Event
SPONSORED BY: Diagnostica Stago, Inc.
13 7 2610

  • Supervisor, Special Coagulation and Hematology, New York Presbyterian- Columbia
      Presently, I am both the Supervisor of Special Coagulation and the QA Manager for Specialty Testing at New York Presbyterian Hospital- Columbia. I also am an adjunct professor at SUNY Stony Brook, New York and a guest lecturer at Rutgers in New Jersey. I have given hundreds of lectures on coagulation throughout the world, and presented posters at many conferences. One of my passions is writing, and I have published over 100 articles and worked on 5 text books. I have 32 years of clinical laboratory experience and an additional 6 years working in industry with clinical trial experience. I am on the Editorial Board for Laboratory Medicine and Advance for Administrators of the Laboratory. Additionally, my involvement with ASCP has put me on the Workshop committee, Board of Registry and currently I serve as co-chair of the Editorial Board. I am also on the executive committee of NASCOLA (North American Specialized Coagulation Laboratories Association). I am a member of the CLSI guidelines committee: Hematology Area and worked on the CLSI Lupus Anticoagulant 2010-2014 and chair the CLSI Factor Assay document.


    This webinar will look at the principles of the assays available to monitor heparin.  The most frequent assay that is used is the activated partial thromboplastin time (aPTT).  This assay is readily available and inexpensive.  However aPTT reagents are poorly standardized and have different sensitivities to heparin. There is no dose response relationship with heparin.  Due to the analytical and biological variables of heparin, patients respond to it differently.  Laboratories using the aPTT to monitor heparin, need to provide clinicians with a heparin therapeutic range specific for their lot of reagent on their analyzer.  An anti-Xa assay is a standardized test that has good precision, and is linear. A heparin assay can provide clinicians with an assay that accurately determines heparin levels and can improve overall patient heparin management.

    The objectives of this webinar are:

    • Describe the principle of the aPTT and  heparin assays
    • Identify the advantages of each assay and outcomes for patient care
    • Enhance problem solving skills by analyzing data from case studies.

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