MAR 11, 2020 9:00 AM PDT

Keynote Presentation: The BRAIN Initiative and its Promise for the Treatment of Neuro/Mental/Substance Abuse Disorders

Presented at: Neuroscience 2020
C.E. Credits: P.A.C.E. CE Florida CE
  • Director, National Institute of Neurological Disorders and Stroke
      Dr. Koroshetz serves as Director of the National Institute of Neurological Disorders and Stroke. He joined NINDS in 2007 as Deputy Director and has held leadership roles in a number of NIH and NINDS programs including co-leading the NIH's BRAIN Initiative, the NIH Blueprint for Neuroscience, the Traumatic Brain Injury Center collaboration between the NIH intramural and the Uniformed Health Services University, the Helping to End Addiction Long Term (HEAL) Initiative, the Common Fund's Undiagnosed Disease and the Acute to Chronic Pain Transition programs,.and he was instrumental in founding the NIH Office of Emergency Care Research, Before joining NINDS, Dr. Koroshetz served as Vice Chair of the neurology service and Director of stroke and neurointensive care services at Massachusetts General Hospital (MGH). He was a professor of Neurology at Harvard Medical School (HMS) and led neurology resident training at MGH between 1990 and 2007. Over that same period, he co-directed the HMS Neurobiology of Disease Course with Drs. Edward Kravitz and Robert H Brown. A native of Brooklyn, New York, Dr. Koroshetz graduated from Georgetown University and received his medical degree from the University of Chicago. He trained in internal medicine at the University of Chicago and Massachusetts General Hospital. He then trained in Neurology and Neuroscience at MGH and Harvard Neurobiology focusing on how synaptic mechanisms might contribute to neuronal death. His early research in the lab and clinic focused on Huntington's disease and with the team at MGH performed the first study of pre-symptomatic testing based on linkage analysis. A major focus of his clinical research career was the development of measures in patients that reflect the underlying biology of their conditions. This led to brain the development and validation of imaging techniques including Magnetic Resonance (MR) spectroscopy in Huntington's disease; diffusion/perfusion MR and CT X-ray angiography and perfusion imaging in stroke. These stroke imaging tools are now commonplace in stroke care. Guided by these tools he pioneered acute clot removal for acute stroke patients with large artery occlusion which is now practiced at Comprehensive stroke centers around the country. He played a significant role in the revolution in acute stroke care in the US and the growth of the neurointensive care field.


    The US Brain Research through Advancing Innovative Neurotechnologies is a research program focused on building fundamental knowledge of how brain circuits process information to enable human behavior. Research began in 2014 and considerable progress has occurred to open up extraordinary research possibilities for understanding the circuits underlying animal and human behavior. These pose new opportunities for dissecting the circuits that underlie neuro/mental/substance abuse disorders. BRAIN Initiative research has already included advances in brain recording and stimulation for neuro/mental health disorders such as closed-loop simulation for Parkinson's, Essential Tremor and Epilepsy. However, it's major impact will come from the application of technologies to patients that are now in animal studies. These will include new brain activity monitoring techniques to serve as diagnostic readouts of neural circuits. New therapies will come from genomic -enabled precision modulation of specific brain cell types by chemicals, electromagnetic, ultrasound energy or other controlling technologies. In addition to the US program complimentary programs in Europe, the Human Brain Project, Japan (BRAIN/MINDS), Korea, Australia and soon China will add to this scientific revolution. In the past Neurology has been built off of neuropathology and neuroanatomy with the patient's symptoms/deficits presumed due to interruption of these static features. The BRAIN Initiatives will bring the previously invisible dynamic features of brain circuits into Neurology, Psychiatry and NeuroSurgery.

    Learning Objectives:

    1. Understand the potential for new Neurotechnologies to enable powerful abilities to monitor, modulate, and map brain circuits.

    2. Understand the promise for new Neurotechnologies to more effectively diagnose and treat neuro/mental/substance abuse disorders.

    3. Become aware of ethical questions that are raised by the new Neurotechnologies.

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