MENU
MAY 10, 2017 4:00 AM PDT

Stabilization of native & functional membrane proteins for drug discovery

Speaker
  • Chief Scientific Officer, CALIXAR
    Biography
      Anass Jawhari, holds a Ph.D. in biochemistry & structural biology from Louis Pasteur University (Strasbourg, France), obtained under the supervision of Professor Dino Moras (IGBMC & French academy of Science). He worked as research associate at the Scripps Research Institute (La Jolla, US) and at the Gene Center (Munich, Germany) before joining Transgene as Research Investigator. He is now Chief Scientific Officer at CALIXAR. He has more than 18 years' experience in research & development projects related to molecular aspects of vaccine, cancer & infectious diseases. Anass is also member of different membrane proteins consortiums (GPCR and ion channels) and board member of different institutions including SOJ immunology editorial (US) and Chem2stab consortium (France).

    Abstract

    CALIXAR has developed an innovative detergent/surfactant based approach consisting on native isolation and stabilization of therapeutic membrane protein targets such as GPCRs, ion channels, transporters. Here we will explain how this approach can stabilize membrane proteins by modifying their chemical environment instead of their native sequence. We will illustrate using case studies on targets of high medical relevance produced in their most native state without any single mutation, truncation or fusion and that were solubilized, affinity purified while maintaining their functional and structural integrities. A recent collaboration was initiated with Thermo Fisher Scientific as the world leader on the expression of difficult to express proteins. This collaborative effort we will help us tackle the production and characterization of very challenging but very promising and highly druggable targets such as GPCRs, ion channels & transporters. This native isolation approach represents a new hope for the development of more accurate drug discovery (SBDD, FBDD, Antibody discovery & vaccine) and provide a serious alternative to classical protein engineering approaches.


    Show Resources
    MAY 10, 2017 4:00 AM PDT

    Stabilization of native & functional membrane proteins for drug discovery


    Specialty

    Molecular Biology

    Cell Biology

    Biotechnology

    Cancer Research

    Biochemistry

    Immunology

    Biomarkers

    Cell Culture

    Drug Discovery

    Molecular Diagnostics

    Bioinformatics

    Microbiology

    Pcr/rt-Pcr/real-Time Pcr

    Infectious Disease

    Genetics

    Geography

    Europe39%

    North America31%

    Asia15%

    South America8%

    Africa3%

    Oceania1%

    Registration Source

    Website Visitors100%

    Job Title

    Research Scientist24%

    Student22%

    Scientist14%

    Executive10%

    Post Doc8%

    Educator/Faculty6%

    Facility/Department Manager5%

    Medical Doctor/Specialist4%

    Medical Laboratory Technician3%

    Lab Management2%

    Biologist2%

    Organization

    Academic Institution14%

    Research Institute9%

    Biotech Company7%

    Clinical Laboratory4%

    Life Science Company3%

    Hospital3%

    Pharmaceutical Company2%

    Ambulatory Care2%

    Veterinary School2%

    Medical School2%

    Government1%

    Non-Profit Organization1%

    Industrial Company1%

    Medical Center1%

    Other2%


    Show Resources
    Show Resources
    Attendees
    • See more
    Connect with us