D-dimer is used in the clinical evaluation of suspected venous thromboembolism (VTE). Newer measurement methods show high sensitivity for this test, and in combination with pretest probability assessment, have a high negative predictive value for exclusion of VTE, obviating the need for many imaging procedures, optimizing healthcare resource utilization. This presentation will highlight the evidence supporting the clinical utility of D-dimer in VTE: upper extremity, lower extremity, recurrent lower extremity DVT and pulmonary embolism. The American Society of Hematology 2018 updated clinical practice guidelines outlining an evidence-based strategy for the diagnostic evaluation of VTE will be reviewed.
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