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For nearly a decade, Peter C. Adamson, MD served as Chair of the Children's Oncology Group (COG), a National Cancer Institute (NCI) supported international consortium of more than 220 childhood centers that conducts clinical-translational research, including large-scale clinical trials, in children with cancer. After a long and distinguished career in academia, Dr. Adamson recently joined Sanofi, Inc. as Global Head, Oncology Development and Global Head, Pediatric Innovation. Dr. Adamson is Professor Emeritus at the Perelman School of Medicine of the University of Pennsylvania. He is Board Certified in Pediatric Hematology/Oncology and Clinical Pharmacology. Dr. Adamson was appointed by President Obama and serves on the National Cancer Advisory Board (NCAB) and has served as a member of the Blue Ribbon Panel for Vice President Biden's National Cancer Moonshot Initiative. Prior to becoming Chair of the COG in 2011, Dr. Adamson was Director for Clinical and Translational Research at The Children's Hospital of Philadelphia, as well as Chief of the Division of Clinical Pharmacology and Therapeutics. Other past roles include being co-Director of the University of Pennsylvania's - CHOP Clinical Translational Science Award (CTSA), Program Director of the General Clinical Research Center (GCRC) and Principal Investigator of CHOP's Pediatric Pharmacology Research Unit (PPRU).
As a veterinarian and neurosurgeon, Dr. Chambers is a strong proponent of the One Health Initiative, an effort to improve animal and public health worldwide and strengthen medicine by working together. She is the founder of the Alabama Comparative Oncology Network, principal investigator of the Southeastern Comparative Oncology Network, and founding member of the Comparative Brain Tumor Consortium at the Center for Cancer Research, NIH National Cancer Institute - each a collaboration of veterinary and medical scientists and clinicians working together to identify genetic targets for treatment of disease through comparative genomics. Dr. Chambers is the principal investigator of the "CANINE" immunotherapy trial, a collaboration between neuroscientists and clinicians at UAB and regional colleges of veterinary medicine funded by the NIH as part of the Cancer Moonshot Initiative to support cancer research. The research is aimed at identifying histopathologic and genetic similarities and evaluating novel therapies of brain tumors in both people and pets.
Having spent his childhood in the company of a wide variety of animals, Dr. Eward fulfilled a lifelong dream of becoming a small animal veterinarian in 2000 when he graduated from Auburn University's College of Veterinary Medicine. He was particularly captivated by his patients with cancer and decided to pursue this interest further. In 2002, he returned to school, receiving an MD degree from the University of Vermont. He currently is on faculty at Duke University with an adjunct appointment at the North Carolina State College of Veterinary Medicine. He spends the first part of the week taking care of humans with cancer and the latter part of the week taking care of animals with cancer. As an Orthopaedic Oncologist, he specializes in preserving and reconstructing limbs that have been jeopardized by a type of cancer called Sarcoma. Given his dual roles in human and animal health, Dr. Eward is committed to using a One Medicine approach to solving the terrible problem that cancer presents to all of us, whether we walk on two legs or four. He runs a lab at Duke that attempts to identify common elements between types of cancer across different species.
Dr. Patterson-Kane received her veterinary degree and PhD from Massey University, New Zealand. She completed specialty training in the field of veterinary anatomic pathology at the University of Florida followed by the University of Kentucky, before becoming board-certified in 1999. Dr. Patterson-Kane was a faculty member at the Royal Veterinary College (University of London), and then the University of Queensland (Australia), before holding the Chair in Veterinary Pathology at the University of Glasgow (United Kingdom). After leaving academia in 2014 she worked in private diagnostics and the biotechnology industry before joining the Morris Animal foundation as Chief Scientific Officer in 2019.
Dr. Patterson-Kane’s research interests are broad, including cellular stress and ageing, and cancer pathology. She is co-author of the only currently available equine oncology textbook, ‘Clinical Equine Oncology’.
Brief Faculty Profile - Dr. Lee is Professor of Pediatrics and DiMarco Family Endowed Chair in Cell Based Therapy at Nationwide Children's Hospital. He is the founding Director of the Cellular Therapy and Cancer Immunotherapy Program, a joint program between NCH and The Ohio State University James Cancer Hospital. Dr. Lee conducts clinical and translational research on natural killer (NK) cells and their potential for cancer immunotherapy. His laboratory identified a crucial role for IL-21 and STAT3 signaling in NK cell function and proliferation, which has enabled a method for large-scale propagation of clinical-grade NK cells for adoptive transfer. NK cells expanded with this approach have been infused into adult and pediatric patients with leukemia, brain tumors, and solid tumors in investigator-initiated Phase I trials. Dr. Lee is chair of the Cellular Therapy Strategy Group for the Pediatric Blood and Marrow Transplant Consortium, member of the NIH Novel and Exceptional Technology and Research Advisory Committee and member of the Cell Therapy Steering Committee of the Children's Oncology Group. His work in cancer immunotherapy and cellular therapy has been supported by NIH, DOD and numerous foundation research grants, and has led to over 100 peer-reviewed publications, patents, and commercial licenses. Dr. Lee practices clinically in the area of bone marrow transplantation, with a particular interest in haplotransplantation and cellular therapy.
Our translational research program focuses on a comparative approach, utilizing immunologically intact, canine patients with spontaneous cancer. This comparative approach provides a unique opportunity to evaluate the safety and effectiveness of next generation immunotherapies in a parallel canine patient population that presents the same challenges to effective immunotherapy as seen in human patients. The aim of this approach is to accelerate the translation of the most promising pre-clinical discoveries into the human clinic. Our lab is actively involved in developing the canine "model" for evaluating CART cell therapies. We have successfully translated several promising strategies to generate anti-tumor immunity from the lab and pre-clinical murine models into client owned dogs suffering from lymphoma, osteosarcoma and hemangiosarcoma. Our lab evaluates the immunological consequences of immune-based therapies in client owned dogs using flow cytometric phenotyping and functional assays including cytokine production, cytotoxicity assays and ELISpot assays to investigate canine T cell responses. Dr. Mason leads a multi-institutional clinical trial evaluating the safety and efficacy of a recombinant Listeria to prevent metastatic disease in dogs with osteosarcoma. She also leads the coordinating center for Canine Cancer Immunotherapy Trials (U24) as part of the Cancer Moonshot program. The lab has extensive experience in methodology to robustly expand and genetically modify canine T cells ex vivo and is the first to perform clinical trials using CART cells in client owned dogs with treatment naïve or relapsed B-NHL. This single site trial is performed at the Veterinary Hospital of the University of Pennsylvania.
Dr. Rodney Page, Director of the Flint Animal Cancer Center Professor and Director of the Flint Animal Cancer Center Stephen Withrow Presidential Chair in Oncology College of Veterinary Medicine and Biomedical Sciences Colorado State University Dr. Page received his DVM from Colorado State University and completed specialty training in the field of medical oncology in NYC. Dr. Page is board-certified in Internal Medicine and Oncology. He was a faculty member at North Carolina State University prior to his appointment at Cornell University as the founding director of The Sprecher Institute for Comparative Cancer Research. In 2005 Dr. Page was appointed Chair of the Department of Clinical Sciences. Dr. Page returned to Colorado as the Director of the Flint Animal Cancer Center in 2010 (www.csuanimalcancercenter.org ). Dr. Page has authored or co-authored about 130 peer-reviewed manuscripts, 30 book chapters and co-edited the 5th Edition of Withrow & MacEwen's Small Animal Clinical Oncology in 2012. Dr. Page's research interests have recently been focused on a 'One Medicine' approach to cancer. He has served as PI of the Golden Retriever Lifetime Study since 2008 and has initiated a national effort to bring translational and comparative oncology to a greater audience.
Elias Sayour, MD, PhD is an Associate Professor of Neurosurgery and Pediatrics and Principal Investigator of the RNA-Engineering Lab at the University of Florida. He is a NIH-funded investigator who functions as the Director of the Pediatric Cancer Immunotherapy Initiative (PCI2) of the UF Health Cancer Center and Vice Chair of the UFHCC Scientific Review Monitoring Committee. As a board-certified pediatrician and oncologist, Dr. Sayour has extensive translational experience as PI/Co-I on several human trials. His translational efforts are also focused on new pipeline technologies including a novel lipid-nanoparticle (NP) formulation that his team has pioneered for the immunologic treatment of cancer currently being tested in canine (pet dog) patients with terminal brain cancer before translation into dedicated human studies.
Dr. Connie Sommers is a Program Director at the ImmunoOncology Branch in the Developmental Therapeutics Program in the Division of Cancer Treatment and Diagnosis in the National Cancer Institute. Her grant portfolio covers all aspects of immuno-oncology including immune checkpoint therapies, adoptive cell therapies, combination therapies, and multiple preclinical model systems including canines. She has co-organized conferences on adverse events of immune checkpoint inhibitor therapy, cell-based therapies for the treatment of solid tumors, and combination radiation therapy and immunotherapy . Her research background is in breast cancer and T cell immunology.
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