In Clinical Chemistry Malate Dehydrogenase has the following applications:
+   Determination of CO2/bicarbonate in biological fluids in conjunction with Pep-Carboxylase
+   Indicator enzyme for the determination of serum GOT (Glutamic Oxaloacetic Transaminase)/AST (Aspartate transaminase) which is an indicator of liver function
+   To determine metabolites e.g. Oxaloacetate and Malate