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Inborn errors of metabolism (IEMs) are rare, devastating disorders caused by pathogenic variants in genes encoding key metabolic enzymes, with the liver playing a critical role in over 140 I...
A fundamental challenge for cystic fibrosis (CF) gene therapy is ensuring sufficient transduction of airway epithelial cells to achieve therapeutic correction. Vehicles such as lysophosphati...
Join us for an insightful webinar on the use of polygenic risk scores (PRS) for cardiovascular disease (CVD). The analysis of genetic variation across large populations plays a crucial role...
Join us for an insightful webinar on the use of polygenic risk scores (PRS) for cardiovascular disease (CVD). The analysis of genetic variation across large populations plays a crucial role...
Learning Objectives 1. Discuss Neoantigen Mechanisms: Gain a comprehensive understanding of the mechanisms by which neoantigens are generated and recognized by the immune system, including t...
The 21st Century Cures Act, along with the FDA's Real-World Evidence (RWE) framework, has established a foundation for incorporating real-world data (RWD) into regulatory decision-making...
Solute carriers include numerous uptake transporters that serve as major regulators of drug absorption, disposition, and clearance. Indeed, drug interactions or genetic variation that alter...
Pancreatic ductal adenocarcinoma (PDAC) is characterized clinically by poor survival and mechanistically by KRAS- and autophagy-dependent growth. We and others previously demonstrated that i...
There are known health outcome disparities among those with pancreatic neuroendocrine tumors (pNET) of minority race and those living with adverse social determinants of health (SDOH) (rural...
Immunotherapy has changed the landscape of oncology, improving survival rates for many patients across a variety of malignancies. Two antibody-based immunotherapies, immune checkpoint inhibi...
To determine efficacy of specific complementary therapies to advance evidence-based, integrative healthcare, the complementary modality should first be introduced to stakeholders to determin...
Engineered immune cell therapies offer the promise of more tailored interventions than traditional systemic checkpoint blockades, but so far remain ineffective across the majority of clinica...
Cancer neoantigens arise from protein-altering somatic mutations in tumor and rank among the most promising next-generation immuno-oncology agents when used in combination with immune checkp...
Genomic research has long been skewed toward European populations, leading to significant underrepresentation of Non-European groups in both research studies and genomic databases. This bias...
Fluorescence microscopy offers robust, multi-parametric and scalable analysis of cell level activity in heterogenous populations with spatial and temporal resolution, often critical for effe...
The cellular physiology of microbes can vary significantly within a population, even when exposed to identical external conditions. Recent theoretical and experimental studies have shown tha...
Heart failure, in the simplest of terms, indicates that a problem with the ventricles is preventing the heart from filling and/or pumping correctly. It is the result of a complex mechanical...
This webinar is designed to explore the fundamental characteristics of reverse transcriptases and the essential factors that play a pivotal role in achieving high-quality cDNA synthesis from...
The quest to decipher the complex molecular events underpinning cell polarity and organelle segregation during eukaryotic cell division presents a formidable challenge. A predominant focus o...
abstract Learning Objectives Understand how the health disparity affects ordering M-protein testing at the right time. Discuss Analytical considerations of the test panel/methods ordered Ide...
The disposition of antibody-based therapeutics is generally determined by both target-mediated and non-target processes, the latter being an often-overlooked aspect. Target-independent liabi...
A unique opportunity to deepen understanding of how labs can contribute to antibiotic stewardship efforts by running efficient Procalcitonin testing, yielding significant impacts on patient...
One of the primary limitations in drug discovery and toxicology research is the lack of good model systems between the single cell level and animal or human systems. This is especially true...
A microphysiological system is a 3D in vitro model that mimics human tissue environments with high physiological relevance. This approach enhances our understanding of disease mechanisms, dr...
Numerous biomedical applications have been described for liver-humanized mouse models, such as in drug metabolism or drug-drug interaction (DDI) studies. However, the strong enlargement of t...
Super-resolution microscopy, or nanoscopy, enables the use of fluorescent-based molecular localization tools to study molecular structure at the nanoscale level in the intact cell. Analysis...
Organisms sense and respond to changes in the environment through signal transduction pathways. Pathways like highly conserved Mitogen-Activated Protein Kinase (MAPK) pathways are composed o...
Inborn errors of metabolism (IEMs) are rare, devastating disorders caused by pathogenic variants in genes encoding key metabolic enzymes, with the liver playing a critical role in over 140 I...
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