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The practice of diagnostic pathology has gone through a disruptive transformation in which multiple tools such as digital imaging, advanced artificial intelligence algorithms, and computer-a...
Our presenter Jonathan Nowak, will discuss representative multiplexed assays for protein and RNA profiling built in the lab and discuss the necessary elements to operationalize this type of...
In this webinar, we will briefly introduce Vizgen’s Vizgen® MERSCOPE® Platform for spatial transcriptomics. Following this introduction, we will showcase the capabilities of ME...
Inflammation is associated with cognitive decline and the pathogenesis of Alzheimer's disease, although exact pathways remain elusive. To further explore the role of inflammation, we uti...
How do we gain a comprehensive understanding of the mechanisms underlying complex behaviors occurring in complex and dynamic environments? Almost any answer to this question involves a multi...
Brian Uzzi presents two studies on innovation in science. Study one examines conditions favoring the generation of innovative, high impact ideas and study two examines the conditions that ef...
The rapid growth of technologies capable of comprehensively collecting, managing, and allowing us to gain an in-depth picture of the brain, nervous system, and behavior across diverse spatia...
Learning Objectives: 1. Describe language disturbances in schizophrenia and its risk states. 2. Describe face expression disturbances in schizophrenia and its risk states. 3. Describe ethica...
The nervous system of social species has evolved to perceive and evaluate signals within a social context. Social information therefore must impact how the brain processes information, yet l...
Join us for a thought-provoking webinar titled, "Breaking Barriers in STI Clinical Management: Addressing Resistance Challenges and Incorporating New Diagnostic Approaches," featur...
Parkinson’s disease (PD) belongs the group of synucleinopathies characterized by progressive aggregation of the neuronal protein alpha-synuclein (asyn). Diagnosis and evidence of disea...
Learning Objectives: 1. Review the basic principle of 3D microscopy. 2. Recognize the pathophysiology of Parkinson disease. 3. Demonstrate knowledge on how alpha-synuclein aggregates spread...
The advancement in ultra-sensitive immunoassays and highly specific immunoprecipitation mass spectrometry (IPMS) methods, complimented by an increasing number of well-characterised research...
Infant motor development is measured clinically using short, subjective, observational scales. While these scales are useful, they have limitations. They provide us with a “snapshot&rd...
Protein misfolding and aggregation are key features observed in numerous neurodegenerative conditions, such as Alzheimer's and Parkinson's disease. The oligomers formed during the ag...
Recent advances in gene editing has allowed the generation of advanced rodent research models, mimicking some aspects of human conditions. For neurodegenerative disorders such as Alzheimer&r...
Brain organoids are self-assembled three-dimensional cellular aggregates with cell types and tissue architectures that resemble the embryonic human brain. As they recapitulate many key featu...
DBS for obsessive-compulsive disorder (OCD) achieves clinical benefit in 66% of treatment-resistant patients. However, there is still a lack of a fundamental understanding of the neurophysio...
Drug discovery programs require a robust panel of models and assays to identify and validate drug targets, support compound optimisation, and run mechanistic studies. Fully human in vitro mo...
The ultimate goal of neuroscience is to understand and explain real-world behavior in terms of brain activity, and to use these insights to develop therapeutic approaches for neural disorder...
Social interactions are essential for the survival of social animals. Across species the medial prefrontal cortex (mPFC) has been identified as a hub of social cognition. In mouse models we...
Robots are useful tools for studying the nervous system and its control of body mechanics because they can be used to perform experiments that would be difficult to perform with an animal. F...
Transdisciplinary knowledge producing teams (TDKPTs) dedicate their efforts to solving wicked problems. Successful TDKPTs embody characteristics of complex adaptive systems (CAS) and exempli...
Many behaviors are learned through trial and error by matching performance to internal goals, yet neural mechanisms of performance evaluation remain poorly understood. We recorded basal gang...
Vestibular sensation anchors our perception of the environment and is crucial for maintaining balance during locomotion. Vertebrate animals use the evolutionarily conserved vestibular system...
Speech neuroprostheses have the potential to restore communication to people living with paralysis, but naturalistic speed and expressivity are elusive. Here we use high-density surface reco...