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Amerigo Scientific

Amyloid Precursor Protein β-Secretase Inhibitor | Amerigo Scientific

Amyloid Precursor Protein β-Secretase Inhibitor

MW: 1651.8

H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-OH

This statin analogue of an amyloid precursor protein fragment is an effective inhibitor of β-secretase from human brain. β-secretase is responsible for proteolytic cleavage of N-terminal fragment from amyloid precursor protein between residues 671 and 672, leading to the generation of the soluble form of

amyloid precursor protein. The C-terminal fragment is further processed by gamma-secretase to form the amyloid β-peptide assumed to be the pathological component of Alzheimers's disease.

Sinha S. et al. (1999) Nature 402, 537.

1mg

5mg

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ABOUT THE COMPANY

Amerigo Scientific is a distribution company focused on providing critical products and services to the biomedical and life science research communities. Although a new company, Amerigo Scientific's founder has had more than 20 years of rich experience in the biomedical and biochemical fields, and has established close contacts with key personnel in...
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