This active molecular is a SNDR (serotonin-norepinephrine-dopamine reuptake) inhibitor It was originated by Bristol-Myers Squibb for the treatment of major depressive disorder. In Feb 2013, Phase-II clinical trials in Major depressive disorder (treatment-experienced) in Argentina was on going. In May 2013, Bristol-Myers Squibb completed a phase II trial in Argentina, Australia, Austria, Canada, France, India, Italy, Puerto Rico, South Africa, Spain, United Kingdom and USA. In Oct 2013, Bristol-Myers Squibb discontinued a phase II trial in Major depressive disorder (treatment resistant) because of its increased capacity for side effects as well as potential for abuse.