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BOC Sciences

(Val34)-Amyloid _-Protein (1-40) | BOC Sciences

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Cerebral amyloid angiopathy (CAA) is a common manifestation of Alzheimer's disease, characterized by amyloid-A_ vascular deposition in >80% of cases. Mutations at sites 21-23 (such as the Dutch mutation E22Q) are primarily associated with CAA, although they present with significantly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V A_ mutant lies outside this hot spot, showing a similar bleeding phenotype, though less aggressive than the widely studied Dutch variant.

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BOC Sciences
BOC Sciences specializes in small molecule synthesis, biosynthesis, purification, and characterization. It provides a wide range of research chemicals and biochemicals, including inhibitors, building blocks, carbohydrates, nucleosides, nucleotides, GMP Products, impurities and metabolites, APIs, natural compounds, ADCs, stem cell molecules and chiral compounds.
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